FlyBase Allele Report: Dmel\Rab11[UASp.YFP]

General Information

Symbol

Dmel\Rab11^UASp.YFP

Species

D. melanogaster

Name

FlyBase ID

FBal0215410

Feature type

allele

Associated gene

Dmel\Rab11

Associated Insertion(s)

Carried in Construct

P{UASp-YFP.Rab11}

Also Known As

UAS-YFP-rab11, UAS-Rab11-YFP, UAS-YFP:Rab11, YFP-Rab11, UASp-YFP-Rab11, UASp-YFP:Rab11, UAS-Rab11, Rab11-WT

Key Links

Transgenic product class

wild_type

(Zhang et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Zhang et al., 2007)

Mutagen

in vitro construct

(Zhang et al., 2007)

Progenitor genotype

Carried in construct

P{UASp-YFP.Rab11}

Cytology

Description

UASp regulatory sequences drive expression of wild-type Rab11 that is tagged at the N-terminal end with YFP.

(Zhang et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Rab11

Tagged with

YFP

yellow fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates motor neuron disease

modeled by scat^HMS01910

(Patel et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | larval stage, with Scer\GAL4^futsch-C380

(Patel et al., 2020)

fertile, with Scer\GAL4^αTub84B.PL

(Zheng et al., 2016)

viable, with Scer\GAL4^αTub84B.PL

(Zheng et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies with overexpression of Rab11^{Scer\UAS.P\T.T:Avic\GFP-YFP} driven ubiquitously by Scer\GAL4^αTub84B.PL are healthy and fertile.

(Zheng et al., 2016)

Expression of Rab11^{Scer\UAS.P\T.T:Avic\GFP-YFP} under the control of Scer\GAL4^ninaE.PT does not result in light-dependent retinal degeneration (flies raised under 12 hour light/12 our dark conditions show a normal electroretinogram amplitude at 3 weeks of age).

(Xiong et al., 2012)

Expression of Rab11^{Scer\UAS.P\T.T:Avic\GFP-YFP} under the control of Scer\GAL4^sca.PU does not lead to an increase in the frequency of bristle twinning on the adult thorax, as compared to controls.

(Karbowniczek et al., 2010)

Expression via Scer\GAL4^pnr-MD237 results in flies with a wild type notum.

(Thomas et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Rab11^UASp.YFP, Scer\GAL4^c306 is a suppressor | partially of abnormal cell polarity | oogenesis phenotype of Scer\GAL4^c306, cactin^KK100507

(Miao et al., 2022)

Rab11^UASp.YFP, Scer\GAL4^c306 is a suppressor | partially of abnormal cell migration | oogenesis phenotype of Scer\GAL4^c306, cactin^KK100507

(Miao et al., 2022)

Rab11^UASp.YFP, Scer\GAL4^futsch-C380 is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4^futsch-C380, scat^HMS01910

(Patel et al., 2020)

Other

Statement

Reference

Rab11^UASp.YFP, Scer\GAL4^futsch-C380, scat^HMS01910 has abnormal locomotor behavior | larval stage phenotype

(Patel et al., 2020)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Rab11^UASp.YFP, Scer\GAL4^sca.PU is a non-enhancer of mesothoracic bristle | adult stage | increased number phenotype of Rheb^UAS.cPa, Scer\GAL4^sca.PU

(Karbowniczek et al., 2010)

Suppressor of

Statement

Reference

Rab11^UASp.YFP, Scer\GAL4^c306 is a suppressor | partially of border follicle cell phenotype of Scer\GAL4^c306, cactin^KK100507

(Miao et al., 2022)

Rab11^UASp.YFP, Scer\GAL4^futsch-C380 is a suppressor | partially of embryonic/larval neuromuscular junction | larval stage phenotype of Scer\GAL4^futsch-C380, scat^HMS01910

(Patel et al., 2020)

Rab11^UASp.YFP, Scer\GAL4^futsch-C380 is a suppressor | partially of NMJ bouton | increased number | larval stage phenotype of Scer\GAL4^futsch-C380, scat^HMS01910

(Patel et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Rab11^{Scer\UAS.P\T.T:Avic\GFP-YFP} does not enhance the bristle twinning phenotype of flies expressing Rheb^Scer\UAS.cPa under the control of Scer\GAL4^sca.PU.

(Karbowniczek et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

50782

y¹ w^*; P{UASp-YFP.Rab11}3

9790

y¹ w^*; P{UASp-YFP.Rab11}sra³²/TM3, Sb¹

Notes on Origin

Discoverer

Comments

Carried in a plasmid and transfected into S2R+ cells to study the subcellular localisation of the protein produced.

(Zhang et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rab11^{Scer\UAS.P\T.T:Avic\GFP-YFP}

Rab11^UASp.YFP

Name Synonyms

Secondary FlyBase IDs

References (34)

Report Sections

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