A 6.5kb genomic fragment encompassing the S6kII transcription unit.
Expression of two copies of S6kIIt6.5 results in reduced operant learning in the heat box; the effect is greater in females than in males. Expression of a single copy of the transgene still reduces this learning but the phenotype is less severe than when two copies are expressed. Expression of one copy of S6kIIign-Δ58-1 in a S6kIIt6.5/Y background results in flies that show a normal training performance in the heat box. However, S6kIIign-Δ58-1/Y; S6kIIt6.5/+ and S6kIIign-Δ24-3/Y; S6kIIt6.5/+ flies perform as well as wild-type flies in pavlovian oflactory conditioning memory tests.
S6kIIt6.5 rescues S6kIIign-Δ58-1
S6kIIt6.5 rescues S6kIIign-Δ58-1
The defects in locomotor circadian rhythm seen in S6kIIign-Δ58-1 mutant adults are rescued by S6kIIt6.5 (insertion P{S6kIIt6.5}5-5).
The increased absolute bouton number and bouton number per muscle area which is seen at the neuromuscular junction in S6kIIign-Δ58-1 larvae is rescued by S6kIIt6.5.