FB2024_03 , released June 25, 2024
Allele: Dmel\tow754
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General Information
Symbol
Dmel\tow754
Species
D. melanogaster
Name
FlyBase ID
FBal0215227
Feature type
allele
Associated gene
Dmel\tow
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Chung et al., 2007)
Mutagen
Delta2-3 transposase
(Chung et al., 2007)
Progenitor genotype
P{lacW}tow4938
(Chung et al., 2007)
Caused by aberration
Df(3L)tow754
Cytology
Description

Imprecise excision of the P{lacW}tow4938 insertion, resulting in a 7.4kb deletion that removes the entire tow open reading frame (the first noncoding exon and part of the first intron remain) and part of the neighbouring CG10077 gene (sequences encoding 160 amino acids of the 3' end of CG10077-RA are removed).

(Chung et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The wing phenotypes caused by expression of towA1.Scer\UAS under the control of Scer\GAL4arm.PS are relieved in a tow754 homozygous background.

      Homozygotes show a weak increase in the intervein area between wing veins 3 and 4 compared to wild type. The number of campaniform sensilla along wing vein 3 is normal.

      (Ayers et al., 2009)

      Mutant flies show no eye polarity defects.

      (Chung et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      tow[+]/tow754 is an enhancer of visible | dominant phenotype of stanVC31

      (Chung et al., 2007)
      Suppressor of
      Statement
      Reference

      tow[+]/tow754 is a suppressor | partially of abnormal planar polarity phenotype of Scer\GAL4hs.2sev, fzUAS.cAa

      (Chung et al., 2007)
      Other
      Statement
      Reference

      shaVB13, tow[+]/tow754 has visible phenotype

      (Chung et al., 2007)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      tow754/tow754 is an enhancer of campaniform sensillum of dorsal radius phenotype of ptcConf-1

      (Ayers et al., 2009)

      tow[+]/tow754 is an enhancer of wing hair | increased number phenotype of stanVC31

      (Chung et al., 2007)
      Suppressor of
      Statement
      Reference

      tow[+]/tow754 is a suppressor | partially of ommatidium phenotype of Scer\GAL4hs.2sev, fzUAS.cAa

      (Chung et al., 2007)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ptc16/+ ; tow754/tow754 flies show a slight increase in the mean number of The number of campaniform sensilla (CS) along wing vein 3 compared to wild type, and the percentage of wings with aberrant CS numbers is also increased. The intervein area between veins 3 and 4 is also increased.

      (Ayers et al., 2009)

      The planar polarity defects seen in the eyes of animals expressing fzScer\UAS.cAa under the control of Scer\GAL4hs.2sev are almost completely suppressed by tow754/+ (79.7% of ommatidia are correctly rotated).

      The multiple wing hair phenotype seen in dsh1/Y flies is suppressed by tow754/+, but the defects in polarity of the hairs is not affected.

      The number of multiple wing hairs seen in stanVC31/+ flies is enhanced if they are also carrying tow754/+.

      tow754/+ increases the number of small and multiple wing hairs seen in a shaVB13/shaVB13 background.

      (Chung et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tow754
      (Ayers et al., 2009, Chung et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)