FB2024_03 , released June 25, 2024
Allele: Dmel\MED26MB00704
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General Information
Symbol
Dmel\MED26MB00704
Species
D. melanogaster
Name
FlyBase ID
FBal0212488
Feature type
allele
Associated gene
Dmel\MED26
Associated Insertion(s)
Mi{ET1}MED26MB00704
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - molecular evidence

    (Marr et al., 2014)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}MED26MB00704
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        MED26MB00704 is homozygous lethal. Although homozygous MED26MB00704 embryos hatch, they die before the third larval instar.

        Analysis of genetic mosaics indicate that MED26MB00704 mutant cells are able to proliferate and survive in imaginal discs. However, induction of MED26MB00704-mutant clones in the second larval instar causes extensive lethality at the pupal stage, and surviving adults are frequently missing parts of the wing margin.

        (Marr et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Viable excision lines of Mi{ET1}MED26MB00704 can be recovered after crossing in the Minos transposase, indicating that the insertion was responsible for the lethality.

        (Marr et al., 2014)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        MED26MB00704
        (Bellen, 2007.5.25)
        Med26MB00704
        (Marr et al., 2014)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)