FB2024_03 , released June 25, 2024
Allele: Dmel\egg235
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General Information
Symbol
Dmel\egg235
Species
D. melanogaster
Name
FlyBase ID
FBal0212302
Feature type
allele
Associated gene
Dmel\egg
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Clough et al., 2014, Clough et al., 2007)
Progenitor genotype
Cytology
Description

Two nucleotide substitutions at the 5' end of intron 4.

(Clough et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:24,778,033..24,778,033 [-]
Nucleotide change:

T24778033A

Reported nucleotide change:

T?A

Comment:

Nucleotide substitution in the splice donor for intron 4 from GT to GA. There is a second base mutation (C to A) in the ninth base of the same intron.

(Clough et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      egg235/Df(2R)Dll-MP transheterozygotes are semi-lethal, display a very low male:female ratio, and the few males die within 2-3 days; egg235/Df(2R)ED4065 transheterozygotes are near lethal and no adult males eclose. egg235/Df(2R)Dll-MP and egg235/Df(2R)ED4065 transheterozygous adults exhibit shaky, uncoordinated movements and held-out wings that are incompletely expanded, as compared to controls; the locomotor and wing phenotypes of egg235/Df(2R)Dll-MP transheterozygotes are more pronounced in males than in females.

      (Clough et al., 2014)

      89.2% of egg235/Df(2R)Dll-MP females survive to adulthood, but only 27.8% of egg235/Df(2R)Dll-MP males survive to adulthood.

      (Brower-Toland et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Su(var)3-96, egg[+]/egg235 has polytene chromosome phenotype

      (Brower-Toland et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      egg235/+ reduces condensation of polytene chromosome 4 in Su(var)3-96 mutants. The chromosome is often broader and shorter than in wild type.

      (Brower-Toland et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      egg235
      (Song et al., 2018, Yu et al., 2015, Clough et al., 2014, Wang et al., 2014, Brower-Toland et al., 2009, Clough et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)