FB2024_03 , released June 25, 2024
Allele: Dmel\Cad99C21-6
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General Information
Symbol
Dmel\Cad99C21-6
Species
D. melanogaster
Name
FlyBase ID
FBal0212150
Feature type
allele
Associated gene
Dmel\Cad99C
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(D'Alterio et al., 2005)
Progenitor genotype
Cad99CGE21034
(D'Alterio et al., 2005)
Cytology
Description

Imprecise excision of P{EP}Cad99CGE21034 results in a small deletion covering the 5'UTR of Cad99C.

(D'Alterio et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cad99C21-8/Cad99C21-6 mutant follicles exhibit a range of defects of microvilli. Microvilli appear substantially shorter than in wild-type. In many cases, apical protrusions appear reduced in number, and they form an irregular, spiky pattern, suggesting that microvilli are abnormally shaped and may be clumped. In other cases, no obvious protrusions are detected or only few microvilli with an abnormal, wavy shape protruded from the apical surface.

      (D'Alterio et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Cad99C21-5/Cad99C21-6 is rescued by Scer\GAL4FRT.Rnor\Cd2.Act5C/Cad99CUAS.fl

      (D'Alterio et al., 2005)
      Comments

      Expression of Cad99CScer\UAS.fl in follicle cells under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C rescues microvillus formation in a Cad99C21-5/Cad99C21-6 mutant background.

      (D'Alterio et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Cad99C21-6
      (D'Alterio et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)