FlyBase Allele Report: Dmel\ph-p[GD17398]

General Information

Symbol

Dmel\ph-p^GD17398

Species

D. melanogaster

Name

FlyBase ID

FBal0210333

Feature type

allele

Associated gene

Dmel\ph-p

Associated Insertion(s)

Carried in Construct

P{GD17398}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD17398}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD17398

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | adult stage | female, with Scer\GAL4^C587

(Li et al., 2016)

neoplasia | adult stage | female, with Scer\GAL4^C587

(Li et al., 2016)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

germarium, with Scer\GAL4^C587

(Li et al., 2016)

Detailed Description

Statement

Reference

Expression of ph-p^GD17398 under the control of Scer\GAL4^C587 (together with tub-Gal80[ts] to limit the time of expression to adulthood) causes tumorigenic accumulation of germline stem cell-like cells (the cell number rises with the time of expression).

(Li et al., 2016)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

17398

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^C587, ph-p^GD17398 has increased cell number | female | adult stage phenotype, suppressible | partially by Scer\GAL4^C587/brm^{K804R.UAS.Tag:HA}

(Li et al., 2016)

Scer\GAL4^C587, ph-p^GD17398 has neoplasia | female | adult stage phenotype, suppressible | partially by Scer\GAL4^C587/brm^{K804R.UAS.Tag:HA}

(Li et al., 2016)

Scer\GAL4^C587, ph-p^GD17398 has increased cell number | female | adult stage phenotype, suppressible by Scer\GAL4^C587/dpp^JF01090

(Li et al., 2016)

Scer\GAL4^C587, ph-p^GD17398 has neoplasia | female | adult stage phenotype, suppressible by Scer\GAL4^C587/dpp^JF01090

(Li et al., 2016)

Scer\GAL4^C587, ph-p^GD17398 has increased cell number | female | adult stage phenotype, suppressible by Scer\GAL4^C587/dpp^JF01677

(Li et al., 2016)

Scer\GAL4^C587, ph-p^GD17398 has neoplasia | female | adult stage phenotype, suppressible by Scer\GAL4^C587/dpp^JF01677

(Li et al., 2016)

Scer\GAL4^C587, ph-p^GD17398 has increased cell number | female | adult stage phenotype, suppressible | partially by dpp^hr56/dpp[+]

(Li et al., 2016)

Scer\GAL4^C587, ph-p^GD17398 has neoplasia | female | adult stage phenotype, suppressible | partially by dpp^hr56/dpp[+]

(Li et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^C587, ph-p^GD17398 has germarium phenotype, suppressible by Scer\GAL4^C587/dpp^JF01090

(Li et al., 2016)

Scer\GAL4^C587, ph-p^GD17398 has germarium phenotype, suppressible by Scer\GAL4^C587/dpp^JF01677

(Li et al., 2016)

Scer\GAL4^C587, ph-p^GD17398 has germarium phenotype, suppressible | partially by dpp^hr56/dpp[+]

(Li et al., 2016)

Scer\GAL4^C587, ph-p^GD17398 has germarium phenotype, suppressible | partially by Scer\GAL4^C587/brm^{K804R.UAS.Tag:HA}

(Li et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The tumorigenic accumulation of germline stem cell-like cells in germaria, characteristic for females expressing ph-p^GD17398 under the control of Scer\GAL4^C587 (together with tub-Gal80[ts] to limit the time of expression to adulthood) is strongly suppressed by co-expression of any of the following: dpp^JF01090, dpp^JF01677 or brm^{K804R.Scer\UAS.T:Ivir\HA1} or by combination with a single copy of dpp^hr56.

(Li et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

17398

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ph-p^GD17398

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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