FB2024_03 , released June 25, 2024
Allele: Dmel\mblGD13374
Open Close
General Information
Symbol
Dmel\mblGD13374
Species
D. melanogaster
Name
FlyBase ID
FBal0210052
Feature type
allele
Associated gene
Dmel\mbl
Associated Insertion(s)
Carried in Construct
P{GD13374}
Also Known As
UAS-mblRNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD13374}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD13374
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4Mef2.PR>mblGD13374 display moderate embryonic lethality (around 17%) increasing to more than 30% in larval stages.

      The body wall musculature of Scer\GAL4Mef2.PR>mblGD13374 third instar larvae display several abnormalities such as muscle splitting as well as loss of muscle fibers or presence of extra fibers. In addition, the muscles display a hyper-contracted phenotype.

      (Picchio et al., 2013)

      Third instar larvae expressing mblGD13374 under the control of Scer\GAL4GMR.PU do not show any significant defects in the lamina plexus in the brain compared to controls but the rhabdomere length in the adult eye is significantly reduced.

      (Marrone et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The contractility index is restored in Scer\GAL4Mef2.PR>mblGD13374 larvae as a result of co-expression of Ca-P60AScer\UAS.mb.

      (Picchio et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mblGD13374
      mblRNAi
      (Marrone et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)