UASt regulatory sequences drive expression of an inverted repeat.
Adults expressing LrrkGD11670 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
LrrkGD11670, Scer\GAL4GMR.PFa is an enhancer of visible | adult stage phenotype of Scer\GAL4GMR.PFa, egrUAS.cMa
LrrkGD11670, Scer\GAL4ple.PU is a suppressor of decreased cell number | adult stage phenotype of DeltaUAS.cUa, Scer\GAL4ple.PU
LrrkGD11670, Scer\GAL4ple.PU is a suppressor of abnormal neuroanatomy | adult stage phenotype of DeltaUAS.cUa, Scer\GAL4ple.PU
LrrkGD11670, Scer\GAL4GMR.PFa is an enhancer of eye phenotype of Scer\GAL4GMR.PFa, egrUAS.cMa
LrrkGD11670, Scer\GAL4ple.PU is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of DeltaUAS.cUa, Scer\GAL4ple.PU
LrrkGD11670, Scer\GAL4ple.PU is a suppressor of dopaminergic PPM1 neuron | adult stage phenotype of DeltaUAS.cUa, Scer\GAL4ple.PU
LrrkGD11670, Scer\GAL4ple.PU is a suppressor of dopaminergic PPM2 neuron | adult stage phenotype of DeltaUAS.cUa, Scer\GAL4ple.PU
LrrkGD11670, Scer\GAL4ple.PU is a suppressor of dopaminergic PPM3 neuron | adult stage phenotype of DeltaUAS.cUa, Scer\GAL4ple.PU
The dot-like small eye phenotype characteristic for flies expressing egrScer\UAS.cMa under the control of Scer\GAL4GMR.PFa is exacerbated further by co-expression of LrrkGD11670 resulting in a 'no eye' phenotype with scar-like and/or necrosis-like tissue present.
The dot-like small eye phenotype characteristic for flies expressing egrScer\UAS.cMa under the control of Scer\GAL4GMR.PFa is partially suppressed by co-expression of Rac1GD17411 RNAi. The rescue of the eye phenotype cannot be made any stronger by expressing Rac1GD17411 together with LrrkGD11670.
The dot-like small eye phenotype characteristic for flies expressing egrScer\UAS.cMa under the control of Scer\GAL4GMR.PFa is partially suppressed by co-expression of Rab21JF03338 RNAi. The rescue of the eye phenotype cannot be made any stronger by expressing Rab21JF03338 RNAi together with LrrkGD11670 RNAi.
The loss of dopaminergic neurons from the PPL1, PPM1/2 and PPM3 clusters in the adult brain characteristic for flies expressing DlScer\UAS.cUa under the control of Scer\GAL4ple.PU (together with tub-Gal80[ts] to limit the time of expression to adulthood) can be prevented by co-expression of LrrkGD11670.