FB2024_03 , released June 25, 2024
Allele: Dmel\ftz-f1GD1450
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General Information
Symbol
Dmel\ftz-f1GD1450
Species
D. melanogaster
Name
FlyBase ID
FBal0209604
Feature type
allele
Associated gene
Dmel\ftz-f1
Associated Insertion(s)
Carried in Construct
P{GD1450}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD1450}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD1450
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ftz-f1GD1450 under the control of Scer\GAL4Hml.Δ results in significantly reduced survival when infected with Leishmania amastigotes, as compared to wild type.

      (Okuda et al., 2016)

      Expression of ftz-f1GD1450 under the control of Scer\GAL4phm.PO results in arrested development at the third instar larval stages, before pupariation. The larvae fail to pupariate and remain at the third instar stage for several weeks. Some larvae arrest development at the second to third instar larval transition. When these larvae are fed with exogenous 20E they are able to pupariate. The prothoracic gland cells show reduced levels of lipid droplets per cell.

      Expression of ftz-f1GD1450 in the follicle cells under the control of Scer\GAL4T155 results in the death of many ovarioles, but those that survive show a reduction in the number of lipid droplets in the follicle cells.

      (Talamillo et al., 2013)

      Adults expressing ftz-f1GD1450 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Expression under the control of Scer\GAL4Mef2.PR results in late pupal lethality.

      (Schnorrer et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 results in lethality before the pupal stage.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ftz-f1GD1450
      Name Synonyms
      Secondary FlyBase IDs
        References (8)