FB2024_03 , released June 25, 2024
Allele: Dmel\ballGD16956
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General Information
Symbol
Dmel\ballGD16956
Species
D. melanogaster
Name
FlyBase ID
FBal0209109
Feature type
allele
Associated gene
Dmel\ball
Associated Insertion(s)
Carried in Construct
P{GD16956}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD16956}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD16956
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Vast majority of flies expressing ballGD16956 under the control of Scer\GAL4Mef2.PU fail to eclose and the surviving adults are flightless. At 29[o]C almost all flies die as early pupae. A number of severe ultrastructural defects are observed in the sarcomeres of indirect flight muscle myofibrils: the Z discs and M-lines are fragmented and the filaments ragged.

      (Katzemich et al., 2015)

      Expression under the control of Scer\GAL41407 results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

      Expression under the control of Scer\GAL41407 results in mild defects in the shape of ganglion mother cells in the larval brain.

      Expression under the control of Scer\GAL41407 results in extreme defects in the shape of neuroblasts in the larval brain.

      (Neumüller et al., 2011)

      Adults expressing ballGD16956 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)
      External Data
      Linkouts
      Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ballGD16956
      Name Synonyms
      Secondary FlyBase IDs
        References (6)