FB2024_03 , released June 25, 2024
Allele: Dmel\Dop1R2GD703
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General Information
Symbol
Dmel\Dop1R2GD703
Species
D. melanogaster
Name
FlyBase ID
FBal0206886
Feature type
allele
Associated gene
Dmel\Dop1R2
Associated Insertion(s)
Carried in Construct
P{GD703}
Also Known As
UAS-DopR2 RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD703}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD703
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Dop1R2GD703 ameliorates the phenotypes seen in a paraquat-induced model of Parkinson's Disease.

      (Cassar et al., 2015)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Dop1R2GD703 in glutamatergic neurons under the control of Scer\GAL4VGlut.PC results in increased resistance of flies to paraquat intoxication. Increased survival rates are seen at 24 hours after ingestion and 2 hours after direct application to the ventral nerve cord (VNC) of decapitated flies.

      Expression of Dop1R2GD703 in dopaminergic neurons under the control of Scer\GAL4ple.PF has no effect on resistance of flies to paraquat intoxication.

      Expression of Dop1R2GD703 in glutamatergic neurons under the control of Scer\GAL4VGlut.PC increases survival rates of decapitated flies following direct application of dopamine to the ventral nerve cord (VNC).

      (Cassar et al., 2015)

      Adults expressing Dop1R2GD703 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      DAMBRNAi#2
      (Sabandal et al., 2021)
      Dop1R2GD703
      Dop1R2RNAi
      (Frighetto et al., 2022)
      DopR2GD703
      Name Synonyms
      Secondary FlyBase IDs
        References (14)