FB2024_03 , released June 25, 2024
Allele: Dmel\BRWD3PX2
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General Information
Symbol
Dmel\BRWD3PX2
Species
D. melanogaster
Name
FlyBase ID
FBal0197972
Feature type
allele
Associated gene
Dmel\BRWD3
Associated Insertion(s)
Carried in Construct
Also Known As
dBRWD3PX2
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(D'Costa et al., 2006)
Progenitor genotype
BRWD3s5349
(D'Costa et al., 2006)
Cytology
Description

Imprecise excision of {lacW}BRWD3s5349 has deleted genomic sequence from +172 (in exon1) to +948 (in exon4) relative to the start of the BRWD3 coding region.

(D'Costa et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      eye | somatic clone

      (D'Costa et al., 2006)

      eye disc & actin cytoskeleton | somatic clone

      (D'Costa et al., 2006)

      eye disc & nucleus | somatic clone

      (D'Costa et al., 2006)
      Detailed Description
      Statement
      Reference

      Somatic clones of BRWD3PX2 homozygous cells do not survive in the adult eye, but eyes developing from discs that contain such clones have visible scars. Retinal sections reveal these scars to be the result of incomplete ommatidia.

      The nuclei of BRWD3PX2 homozygous cells in somatic clones in the late third instar eye disc fail to rise to the apical side of each cell posterior to the furrow as in wild-type. The actin cytoskeleton of these cells is disorganised.

      (D'Costa et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      BRWD3PX2
      dBRWD3PX2
      (Shih et al., 2016, Chen et al., 2015)
      ramPX2
      (D'Costa et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)