FB2024_03 , released June 25, 2024
Allele: Dmel\chinmoUAS.fl
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General Information
Symbol
Dmel\chinmoUAS.fl
Species
D. melanogaster
Name
FlyBase ID
FBal0197457
Feature type
allele
Associated gene
Dmel\chinmo
Associated Insertion(s)
Carried in Construct
P{UAS-chinmo.fl}
Also Known As
UAS-chinmo, UAS-chinmoFL, UAS-5'UTR-chinmo-3'UTR
Key Links
Transgenic product class
wild_type
(Zhu et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Zhu et al., 2006)
Mutagen
in vitro construct
(Zhu et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-chinmo.fl}
Cytology
Description

UASt regulatory sequences drive expression of full length chinmo coding and UTR sequences.

(Zhu et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
chinmo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  brain cancer
      CEA
      (Narbonne-Reveau et al., 2016)
      CEA with prosKK109284
      (Narbonne-Reveau et al., 2016)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  cancer
      modeled by ph-d505, ph-p505
      (Jiang et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of chinmoUAS.fl under the control of Scer\GAL4A3.eya leads to following changes in the testes: an increase in the number of undifferentiated germ and cyst cells throughout the testes (bright DAPI labelled cells, although with normal germ cell ensheathment (DE-cad staining)); most somatic cells show characteristics of cyst stem cells/early cyst cells exhibiting high levels of Tj and Zfh1, but low levels of Eya; most germ cells retain germline stem cells/gonioblasts characteristics, with germ cells residing far from the Hub exhibit high esg levels and individual cells/pairs of cells containing fusomes and not expressing Bam; and excess germ cells and somatic cells often undergo mitosis as single cells when compared to controls.

      Expression of chinmoUAS.fl under the control of Scer\GAL4VP16.nos.UTR does not lead to expansion of germline stem cells (Vasa staining) or cyst stem cells (Tj staining) when compared to controls.

      (Flaherty et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      chinmoUAS.fl rescues chinmoST

      (Ma et al., 2014)

      chinmoUAS.fl/Scer\GAL4ey-OK107 rescues chinmo1

      (Zhu et al., 2006)
      Comments

      Expression of chinmoScer\UAS.fl under the control of Scer\GAL4C587 rescues the somatic cell defects of chinmoST/chinmoST mutant testes.

      (Ma et al., 2014)

      Expression of chinmoScer\UAS.fl, under the control of Scer\GAL4OK107 grossly rescues the phenotypes characteristic of chinmo1 mutant mushroom body neuroblast clones.

      (Zhu et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      chinmoScer\UAS.fl
      chinmoUAS.fl
      Name Synonyms
      Secondary FlyBase IDs
        References (10)