FB2024_03 , released June 25, 2024
Allele: Dmel\M6MB02608
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General Information
Symbol
Dmel\M6MB02608
Species
D. melanogaster
Name
FlyBase ID
FBal0197022
Feature type
allele
Associated gene
Dmel\M6
Associated Insertion(s)
Mi{ET1}M6MB02608
Carried in Construct
Also Known As
M603
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Wittek et al., 2020)

    amorphic allele - molecular evidence

    (Wittek et al., 2020)

    hypomorphic allele - genetic evidence

    (Dunn et al., 2018)

    hypomorphic allele - molecular evidence

    (Zappia et al., 2012)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}M6MB02608
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        M6MB02608/Df(3L)BSC419 embryos exhibit over-elongated dorsal trunks.

        M6MB02608 homozygous stage 16 embryos exhibit defective epithelial barrier.

        M6MB02608 embryonic epidermis exhibit increased Aka::GFP mobility both at tricellular and bicellular junctions.

        (Wittek et al., 2020)

        M6EY07032/M6MB02608 mutant males exhibit a mild rough eye phenotype, as well as a disorganised ommatidium array, defects in ommatidium shape and/or ommatidium fusion and defective or missing bristles. Approximately 20% of M6EY07032/M6MB02608 transheterozygote eyes exhibit an excessive interommatidial space.

        Transheterozygous M6EY07032/M6MB02608 mutant males exhibit a significantly defective phototactic response compared to controls.

        (Zappia et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        M603
        (Zappia et al., 2012, Zappia et al., 2011)
        M6MB02608
        (Schleutker and Luschnig, 2024, Wittek et al., 2020, Bellen, 2007.7.9)
        M6MB
        (Wittek et al., 2020)
        M6P
        (Dunn et al., 2018)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)