UAS regulatory sequences drive expression of mutated Hsap\L1CAM that carries the pathogenic H210Q mutation.
Expression of Hsap\L1CAMH210Q.Scer\UAS under the control of Scer\GAL4OK307 has no effect on Giant Fibre (GF) synapse functionality.
Hsap\L1CAMH210Q.UAS/Scer\GAL4shot-OK307 is a non-suppressor of abnormal neurophysiology | adult stage phenotype of Nrg180ΔFIGQY, Nrgl4
Hsap\L1CAMH210Q.UAS/Scer\GAL4shot-OK307 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Nrg180ΔFIGQY, Nrgl4
Hsap\L1CAMH210Q.UAS/Scer\GAL4shot-OK307 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Nrg849
Hsap\L1CAMH210Q.UAS/Scer\GAL4shot-OK307 is a non-suppressor of abnormal neurophysiology phenotype of Nrg849
Hsap\L1CAMH210Q.UAS/Scer\GAL4shot-OK307 is a non-suppressor of giant fiber neuron | adult stage phenotype of Nrg180ΔFIGQY, Nrgl4
Hsap\L1CAMH210Q.UAS/Scer\GAL4shot-OK307 is a non-suppressor of adult neuromuscular junction | adult stage phenotype of Nrg180ΔFIGQY, Nrgl4
Hsap\L1CAMH210Q.UAS/Scer\GAL4shot-OK307 is a non-suppressor of giant fiber neuron | adult stage phenotype of Nrg849
Hsap\L1CAMH210Q.UAS/Scer\GAL4shot-OK307 is a non-suppressor of giant fiber neuron phenotype of Nrg849
Hsap\L1CAMH210Q.UAS/Scer\GAL4shot-OK307 is a non-suppressor of synapse phenotype of Nrg849
Expression of Hsap\L1CAMH210Q.Scer\UAS does not suppress the giant fibre axon guidance defects seen in Nrg849 mutant flies.
Expression of Hsap\L1CAMH210Q.Scer\UAS under the control of Scer\GAL4OK307 does not suppress the Giant Fibre (GF)-Trochanteral Muscle (TTM) synapse functional and morphological defects seen in flies expressing Nrg180ΔFIGQY in a Nrgl4 mutant background.
Expression of Hsap\L1CAMH210Q.Scer\UAS pre- and post-synaptically, under the control of Scer\GAL4A307 in a Nrg849 heterozygous background does not suppress the Nrg849 giant synapse physiological phenotype.