FlyBase Allele Report: Dmel\Top3β[16]

General Information

Symbol

Dmel\Top3β¹⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0195413

Feature type

allele

Associated gene

Dmel\Top3β

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Wu et al., 2006)

Mutagen

P-element activity

(Wu et al., 2006)

Progenitor genotype

P{EP}Top3β^EP1432

(Wu et al., 2006)

Cytology

Description

Imprecise excision of the P{EP} element, resulting in a 2798bp deletion of the Top3β gene, from the first exon through to the first 3bp of the fourth intron, which corresponds to 36bp upstream of the translation start site to 2758bp downstream. A 3kb fragment of the P{EP} element is left behind.

(Wu et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage (with Top3β²⁶)

(Ahmad et al., 2017)

fertile

(Wu et al., 2006)

viable

(Wu et al., 2006)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage (with Top3β²⁶)

(Ahmad et al., 2017)

NMJ bouton | third instar larval stage (with Top3β²⁶)

(Ahmad et al., 2017)

Detailed Description

Statement

Reference

The third instar larval neuromuscular junction of Top3β²⁶/Top3β¹⁶ transheterozygotes exhibits significantly more branches and boutons than controls.

(Ahmad et al., 2017)

Top3β¹⁶ mutants show no pronounced fertility defects and their lifespan is normal.

(Wu et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Top3β²⁶/Top3β¹⁶ is partially rescued by Scer\GAL4^elav.PU/Top3β^{WT.UAS.Tag:FLAG}

(Ahmad et al., 2017)

Not rescued by

Top3β²⁶/Top3β¹⁶ is not rescued by Scer\GAL4^elav.PU/Top3β^{ΔRGG.UAS.Tag:FLAG}

(Ahmad et al., 2017)

Top3β²⁶/Top3β¹⁶ is not rescued by Scer\GAL4^elav.PU/Top3β^{Y322F.UAS.Tag:FLAG}

(Ahmad et al., 2017)

Top3β²⁶/Top3β¹⁶ is not rescued by Top3β^{C660R.UAS.Tag:FLAG}/Scer\GAL4^elav.PU

(Ahmad et al., 2017)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Top3β¹⁶

(Lee et al., 2018)

Top3β^KO

(Ahmad et al., 2017)

top3β¹⁶

(Xu et al., 2013, Wu et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close