2 of the cysteines in the C2H2 structure of the 3rd Zn-finger (out of four) are mutated to Alanines in a 21kb 'pCaSpeR4-sens' genomic rescue construct.
Amino acid replacement: C?A.
sens3CCg is unable to rescue the external sensory organs in adult sensE2 clones, which lose almost all mechanosensory bristles.
Expression of sens3CCg is unable to rescue the loss of post-orbital bristles in adult sensE2 clones.
Expression of sens3CCg does not rescue the lethality of sensE2 homozygous embryos. sens3CCg also does not rescue the PNS defects associated with sensE2.