FB2024_03 , released June 25, 2024
Allele: Dmel\tupE53
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General Information
Symbol
Dmel\tupE53
Species
D. melanogaster
Name
FlyBase ID
FBal0193936
Feature type
allele
Associated gene
Dmel\tup
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Biryukova and Heitzler, 2005)
Mutagen
ethyl methanesulfonate
(Biryukova and Heitzler, 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: C104Y.

(Biryukova and Heitzler, 2005)

Nucleotide substitution: G?A.

(Biryukova and Heitzler, 2005)

The C104Y mutation is in the 'LIM' domain of the expressed product.

(Biryukova and Heitzler, 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:18,865,488..18,865,488 [-]
Nucleotide change:

G18865488A

Reported nucleotide change:

G?A

Amino acid change:

C104Y | tup-PA; C104Y | tup-PB; C104Y | tup-PC

Reported amino acid change:

C104Y

Comment:

TGC to TAC change in codon C104.

(Biryukova and Heitzler, 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      tupE53/tup[+] is an enhancer of thorax phenotype of ChiE

      (Biryukova and Heitzler, 2005)

      tupE53/tup[+] is an enhancer of scutellar bristle | increased number phenotype of ChiE

      (Biryukova and Heitzler, 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      tupE53 enhances the excess scutellar bristle and thoracic cleft phenotype of ChiE flies when heterozygous.

      (Biryukova and Heitzler, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a dominant enhancer of the ChiE allele.

      (Biryukova and Heitzler, 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      islE53
      (Biryukova and Heitzler, 2005)
      tupE53
      Name Synonyms
      Secondary FlyBase IDs
        References (1)