FB2024_03 , released June 25, 2024
Allele: Dmel\hyxEP9
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General Information
Symbol
Dmel\hyxEP9
Species
D. melanogaster
Name
FlyBase ID
FBal0193880
Feature type
allele
Associated gene
Dmel\hyx
Associated Insertion(s)
P{EP}neurEP9
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Mosimann et al., 2006)
Progenitor genotype
Associated Insertion(s)
P{EP}neurEP9
Cytology
Description

P{EP} insertion within the neur transcription unit. In addition, studies indicate that the element is in the correct orientation to drive overexpression of the neighbouring hyx gene (overexpression from the inserted P{EP} element gives the same phenotype as overexpression of hyxScer\UAS.cMa).

(Mosimann et al., 2006)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of hyxEP9 leads to a partial rescue of the L2-L5 intervein growth and patterning defects cause by expression of ptcScer\UAS.T:Hsap\MYC driven by Scer\GAL4salm.E.

      Co-expression of hyxScer\UAS.cMa with Scer\GAL4C-765 driven ci75.Scer\UAS leads to a striking, albeit incomplete, reversion to wild-type wing morphology. The wings recovered from such crosses often develop extra vein material anterior to wing vein L2, and wing basal cell 1 is never fully restored.

      (Mosimann et al., 2009)

      The wing phenotype of Scer\GAL4salm.E>lgs17E.Scer\UAS flies is suppressed by coexpression of hyxEP9.

      (Mosimann et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      D. Nellen

      (Mosimann et al., 2006)

      T. Montavon

      (Mosimann et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      hyxEP9
      Name Synonyms
      Secondary FlyBase IDs
        References (2)