FB2024_03 , released June 25, 2024
Allele: Dmel\nitoUAS.Tag:MYC
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General Information
Symbol
Dmel\nitoUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0193185
Feature type
allele
Associated gene
Dmel\nito
Associated Insertion(s)
Carried in Construct
P{UAS-nito.FL}
Key Links
Transgenic product class
wild_type
(Jemc and Rebay, 2006)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Jemc and Rebay, 2006)
Mutagen
in vitro construct
(Jemc and Rebay, 2006)
Progenitor genotype
Carried in construct
P{UAS-nito.FL}
Cytology
Description

UASt regulatory sequences drive expression of full length nito tagged at the N-terminal end with Tag:MYC.

(Jemc and Rebay, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
nito
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of nitoScer\UAS.T:Hsap\MYC under the control of Scer\GAL4sev.PR results in a rough eye phenotype in the posterior part of the eye and an overall decrease in eye size. There is a decrease in the number of photoreceptors per ommatidium, rhabdomeres are elongated and there is general disorganisation of the ommatidia.

      Eye discs expressing nitoScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.2sev show a stripe of cell death in the posterior part of the eye disc, which is consistent with the loss of photoreceptors seen approximately seven rows posterior to the furrow (as assayed by elav expression).

      (Jemc and Rebay, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4sev.PR, nitoUAS.Tag:MYC has visible phenotype, enhanceable by spen[+]/spenXFM911

      (Jemc and Rebay, 2006)
      Enhancer of
      Statement
      Reference

      nitoUAS.Tag:MYC/Scer\GAL4sev.PR is an enhancer of visible phenotype of Scer\GAL4sev.PR, spenDN.UAS

      (Jemc and Rebay, 2006)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4sev.PR, nitoUAS.Tag:MYC has ommatidium phenotype, enhanceable by spen[+]/spenXFM911

      (Jemc and Rebay, 2006)

      Scer\GAL4sev.PR, nitoUAS.Tag:MYC has eye phenotype, enhanceable by spen[+]/spenXFM911

      (Jemc and Rebay, 2006)
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of nitoScer\UAS.T:Hsap\MYC enhances the rough eye phenotype caused by expression of spenDN.Scer\UAS under the control of Scer\GAL4sev.PR, resulting in complete loss of organisation in the eye and an increase in necroses in the eye.

      (Jemc and Rebay, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      nitoScer\UAS.T:Hsap\MYC
      nitoUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)