FB2024_03 , released June 25, 2024
Allele: Dmel\VGATMB01219
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General Information
Symbol
Dmel\VGATMB01219
Species
D. melanogaster
Name
FlyBase ID
FBal0192147
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Cytology
    Description

    Mi{ET1}VGATMB01219 is inserted approximately between nucleotides 286 and 287 of the VGAT coding sequence, within the second exon.

    Allele components
    Component
    Use(s)
    Inserted element
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    VGATMB01219 flies, expressing VGATScer\UAS.cFa under the control of Scer\GAL4VGAT and Scer\GAL80ts.αTub84B, to allow rescue past the embryonic lethality to the adult stage do not show any gross anatomical abnormalities in the head or nervous system.

    VGATMB01219 mutant flies, expressing VGATScer\UAS.cFa under the control of Scer\GAL4VGAT and Scer\GAL80ts.αTub84B, to allow rescue past the embryonic lethality to the adult stage, exhibit normal ranges in wing beat frequency and amplitude. These flies do not exhibit differences in optomotor control capacity compared to controls.

    VGATMB01219 mutant flies, expressing VGATScer\UAS.cFa under the control of Scer\GAL4VGAT and Scer\GAL80ts.αTub84B, show a reduced ability to fixate a stripe moving against a uniform white background and a diminished capacity for tracking a stripe moving against a counter-rotating wide-field background in which any displacement of the stripe is matched exactly by motion of the background in the opposite direction. General wide-filed optomotor function is intact in these mutants, while the behavioral deficit in these flies is specific for figure detection computations required to follow or fixate the direction of gaze on a small-field object, and more so for the control of response magnitude rather than timing.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    CG8394MB01219
    VGATMB01219
    VGATminos1
    Name Synonyms
    Secondary FlyBase IDs
      References (3)