FB2024_03 , released June 25, 2024
Allele: Dmel\SwgX118
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General Information
Symbol
Dmel\SwgX118
Species
D. melanogaster
Name
FlyBase ID
FBal0191803
Feature type
allele
Associated gene
Swg
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Montana and Littleton, 2004)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Correlating with the behavioural defects, abnormal spiking activity in the dorsal longitudinal muscles is observed at restrictive temperatures (38oC) in SwgX118/+ mutants.

      (Montana and Littleton, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      SwgX118 has abnormal neurophysiology | heat sensitive phenotype, suppressible by parats1

      (Montana and Littleton, 2004)
      Suppressor of
      Statement
      Reference

      SwgX118/Swg[+] is a suppressor of lethal phenotype of MhcS1

      (Montana and Littleton, 2004)

      SwgX118/Swg[+] is a suppressor of lethal phenotype of MhcS2

      (Montana and Littleton, 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double heterozygotes of MhcS1 or MhcS2 and SwgX118 are semi-lethal with escapers having hypercontracted femurs. Double heterozygotes of SwgX118/+; BrkdJ29/+ flies show femur hypercontraction. Suppression of SwgX118 seizure activity is observed in parats1 SwgX118/+ double mutant hemizygous males at 38oC.

      (Montana and Littleton, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SwgX118
      Name Synonyms
      Secondary FlyBase IDs
        References (1)