FB2024_03 , released June 25, 2024
Allele: Dmel\nocte1
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General Information
Symbol
Dmel\nocte1
Species
D. melanogaster
Name
FlyBase ID
FBal0191615
Feature type
allele
Associated gene
Dmel\nocte
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Glaser and Stanewsky, 2005)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C5119T.

(Sehadova et al., 2009)

Amino acid replacement: Q1707term.

(Sehadova et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:10,466,676..10,466,676 [-]
Nucleotide change:

C10466676T

Reported nucleotide change:

C5119T

Amino acid change:

Q1707term | nocte-PA; Q1707term | nocte-PB; Q1707term | nocte-PC; Q1707term | nocte-PD

Reported amino acid change:

Q1707term

(Sehadova et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      nocte1 mutant adults fail to synchronize circadian locomotor activity to 25[o] C:16 [o]C temperature cycles under constant light (LL) conditions, unlike controls; they have a significantly lower circadian clock entrainment index for locomotor activity rhythms following a 7 h delay under 25[o] C:27 [o]C temperature cycles in LL, compared to controls.

      (Chen et al., 2015)

      Mutant flies show a defect in temperature entrainment of behavioural rhythms; they show no anticipation of the transition to the cold phase and simply react to temperature changes (in contrast, wild-type flies anticipate the transition to the cold phase by an increase of their activity levels).

      nocted07154/nocte1 files do not show normal entrainment to temperature cycles but show normal synchronisation to light-dark cycles in assays studying locomotor rhythms.

      Mutant flies show an uncoordinated phenotype at 37[o]C, with more flies falling over the longer they are exposed to the high temperature. This temperature-dependent uncoordinated phenotype is largely suppressed if the humidity is greater than 90%.

      (Sehadova et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies expressing perBG.T:Ppyr\LUC in a nocte1 background are able to entrain to a 12 hour:12 hour LD cycle at 25oC. In contrast to wild-type flies, perBG.T:Ppyr\LUC nocte1 flies fail to entrain to a 12 hour:12 hour 25oC:18oC temperature cycle in LL; these flies are constantly active throughout both temperatures, except for a drop in activity during a ~1 hour window shortly after transition to the cold phase. Activity levels are higher in the warm phase. Further, the flies fail to entrain to two consecutive warm:cold cycles in LL where the second cycle is phase advanced by 6 hours, instead they abruptly change their activity level at the time of temperature transition. The flies behave similarly to control flies when kept in constant darkness at a variety of constant temperatures.

      (Glaser and Stanewsky, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      nocted07154

      (Sehadova et al., 2009)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: Abolishing bioluminescence rhythms in perBG.T:Ppyr\LUC.

      (Glaser and Stanewsky, 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      nocte
      (Glaser and Stanewsky, 2005)
      nocte1
      (Lobb-Rabe et al., 2022, Yadlapalli et al., 2018, Chen et al., 2015, Sehadova et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)