FlyBase Allele Report: Dmel\nocte[d07154]

General Information

Symbol

Dmel\nocte^d07154

Species

D. melanogaster

Name

FlyBase ID

FBal0186907

Feature type

allele

Associated gene

Dmel\nocte

Associated Insertion(s)

P{XP}nocte^d07154

Carried in Construct

Also Known As

nocte^P

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members and Exelixis, 2005)

Progenitor genotype

Associated Insertion(s)

P{XP}nocte^d07154

Cytology

Description

Insertion in the first intron, which results in the generation of abnormally spliced transcripts.

(Sehadova et al., 2009)

Allele components

Component

Use(s)

Inserted element

P{XP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:10,473,056..10,473,056 [-]

(Sehadova et al., 2009, Gene Disruption Project members and Exelixis, 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor rhythm (with nocte¹)

(Sehadova et al., 2009)

abnormal neuroanatomy | embryonic stage

(Lobb-Rabe et al., 2022)

abnormal neuroanatomy | larval stage

(Lobb-Rabe et al., 2022)

uncoordinated | adult stage | heat sensitive

(Sehadova et al., 2009)

Phenotype Manifest In

embryonic/larval hypodermal muscle | larval stage

(Lobb-Rabe et al., 2022)

larval intersegmental nerve branch ISNb of A1-7

(Lobb-Rabe et al., 2022)

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage

(Lobb-Rabe et al., 2022)

Detailed Description

Statement

Reference

Homozygous and nocte^d07154/nocte¹ files do not show normal entrainment to temperature cycles but show normal synchronisation to light-dark cycles in assays studying locomotor rhythms.

Mutant flies show an uncoordinated phenotype at 37[o]C, with more flies falling over the longer they are exposed to the high temperature. This temperature-dependent uncoordinated phenotype is largely suppressed if the humidity is greater than 90%.

(Sehadova et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

nocte^d07154 is a non-enhancer of abnormal neuroanatomy | larval stage phenotype of dpr10^14-5

(Lobb-Rabe et al., 2022)

NOT Suppressor of

Statement

Reference

nocte^d07154 is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of dpr10^14-5

(Lobb-Rabe et al., 2022)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

nocte^d07154 is a non-enhancer of larval intersegmental nerve branch ISNb of A1-7 phenotype of dpr10^14-5

(Lobb-Rabe et al., 2022)

nocte^d07154 is a non-enhancer of embryonic/larval hypodermal muscle | larval stage phenotype of dpr10^14-5

(Lobb-Rabe et al., 2022)

NOT Suppressor of

Statement

Reference

nocte^d07154 is a non-suppressor of larval intersegmental nerve branch ISNb of A1-7 phenotype of dpr10^14-5

(Lobb-Rabe et al., 2022)

nocte^d07154 is a non-suppressor of embryonic/larval hypodermal muscle | larval stage phenotype of dpr10^14-5

(Lobb-Rabe et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

nocte^d07154 ; smet^unspecified double mutant flies show more severe defects in entrainment to temperature cycles than either single mutant in assays studying locomotor rhythms, indicating an additive effect.

(Sehadova et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

nocte¹

(Sehadova et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG17255^d07154

CG2889^d07154

(Markmiller et al., 2018)

nocte^P

(Lobb-Rabe et al., 2022, Sehadova et al., 2009)

nocte^d07154

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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