FB2024_03 , released June 25, 2024
Allele: Ccap\trahs.PP
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General Information
Symbol
Ccap\trahs.PP
Species
C. capitata
Name
FlyBase ID
FBal0191558
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

An Hsp70 promoter drives expression of the Ccap\tra F1 cDNA. The Hsp70 terminator signal is also present.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

D.melanogaster flies carrying Ccap\trahs.PP and raised at 25oC can be divided into three classes according to the severity of defects seen in XY flies. In the weak class, the majority of XX and XY flies have no obvious sex transformation, having normal external morphology and being fully viable and fertile. However 2% of XY flies in the weak class have male intersexual phenotypes, with reduced abdomen pigmentation, incomplete sex-comb development, and variable feminisation of the external genitalia. In the intermediate class, XY animals have a variety of phenotypes, ranging from male to female-like external morphology. 30% of the animals in this class are intersexes. Finally, in the strong class, XY animals are always strongly feminised; they have female-like reduced abdominal pigmentation, no sex combs on the forelegs and the external genitalia is made up of both male and female tissues. These animals have a body size similar to that of wild-type males. D.melanogaster XY flies carrying Ccap\trahs.PP and exposed to a daily heat shock regimen are strongly transformed towards femaleness, with female-like abdominal pigmentation, reduced or absent sex combs and apparently normal female-like external genitalia. These pseudofemales are sterile. D.melanogaster XX flies carrying Ccap\trahs.PP do not show sexually altered somatic tissues either at 25oC, or after heat shock treatment.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of Ccap\trahs.PP using heat shock in XX ; traunspecified animals results in the development of rudimentary or even almost-normal ovaries. However, these animals fail to lay eggs. XY ; Ccap\trahs.PP traunspecified animals are transformed into somatic females at 25oC (as occurs in XY ; Ccap\trahs.PP animals). However, these individuals have either malformed testes, or lack internal genitalia. The mutant phenotype of XX ; tra2B/Df(2R)trix animals is not rescued by Ccap\trahs.PP.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Ccap\trahs.PP
Name Synonyms
Secondary FlyBase IDs
    References (1)