FB2024_03 , released June 25, 2024
Allele: Dmel\cpbbnd1
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General Information
Symbol
Dmel\cpbbnd1
Species
D. melanogaster
Name
FlyBase ID
FBal0191071
Feature type
allele
Associated gene
Dmel\cpb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Delalle et al., 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q5term.

(Delalle et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:1,705,409..1,705,409 [+]
Nucleotide change:

C1705409T

Amino acid change:

Q5term | cpb-PA; Q5term | cpb-PB

Reported amino acid change:

Q5term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Delalle et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      actin cytoskeleton & eye disc | somatic clone

      (Delalle et al., 2005)

      filopodium | increased number

      (Gonçalves-Pimentel et al., 2011)
      Detailed Description
      Statement
      Reference

      Cultured primary neurons derived from mutant embryos show a significant increase in the number of filopodia compared to control neurons.

      (Gonçalves-Pimentel et al., 2011)

      Recruitment of cells to developing ommatidial clusters occurs normally and without delay in homozygous clones in third larval instar eye discs. The actin cytoskeleton appears abnormal in these discs, with actin accumulating in the mutant cells.

      (Delalle et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      cpbbnd1/cpb[+] is an enhancer of abnormal cell migration phenotype of CskGD9345, Scer\GAL4ptc-559.1

      (Rudrapatna et al., 2014)
      Other
      Statement
      Reference

      CskGD9345, cpbbnd1 has lethal phenotype

      (Rudrapatna et al., 2014)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      cpbbnd1/cpb[+] is an enhancer of wing disc phenotype of CskGD9345, Scer\GAL4ptc-559.1

      (Rudrapatna et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A cpbbnd1 heterozygous mutant background enhances the actin remodelling and subsequent basolateral invasion of epithelial cells seen in flies expressing CskGD9345 in a stripe of cells at the anterior/posterior boundary of the larval wing disc under the control of Scer\GAL4ptc-559.1.

      (Rudrapatna et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      cpbM143

      (Delalle et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      bnd1
      (Delalle et al., 2005)
      cpbbnd1
      (Rudrapatna et al., 2014, Gonçalves-Pimentel et al., 2011, Johnson et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)