FB2024_03 , released June 25, 2024
Allele: Dmel\Rab54
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General Information
Symbol
Dmel\Rab54
Species
D. melanogaster
Name
FlyBase ID
FBal0182045
Feature type
allele
Associated gene
Dmel\Rab5
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Wucherpfennig et al., 2003)
Progenitor genotype
Rab5k08232
(Wucherpfennig et al., 2003)
Cytology
Description

Rab54 is a 14bp insertion of the right long terminal repeat of the P-element that remains after excision.

(Wucherpfennig et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rab54 heterozygotes do not exhibit a discernible phenotype in the adult brain.

      (Rowshanravan et al., 2014)

      Homozygous Rab54 adults exhibit a flightless phenotype in 63% of adult flies.

      (Wucherpfennig et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Rab5[+]/Rab54 is a suppressor of abnormal neuroanatomy phenotype of vap2

      (Rowshanravan et al., 2014)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Rab5[+]/Rab54 is a suppressor of adult brain phenotype of vap2

      (Rowshanravan et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A heterozygous Rab54 mutant background suppresses the vap2 neurodegenerative phenotype.

      (Rowshanravan et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Rab54
      (Rowshanravan et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)