FB2024_03 , released June 25, 2024
Allele: Dmel\cpbF44
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General Information
Symbol
Dmel\cpbF44
Species
D. melanogaster
Name
FlyBase ID
FBal0180370
Feature type
allele
Associated gene
Dmel\cpb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Whited et al., 2004)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?148term.

(Whited et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:1,705,839..1,705,839 [+]
Nucleotide change:

G1705839A

Amino acid change:

W148term | cpb-PA; W148term | cpb-PB

Reported amino acid change:

?148term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Whited et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mir-8Δ/+ ; cpbF44/+ double transheterozygous larvae show a decrease in the number of boutons and in presynaptic arbor expansion at the neuromuscular junction (normalised to muscle area) compared to controls.

      (Loya et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      cpbM143

      (Whited et al., 2004)
      Partially rescued by

      cpbF44/Df(2L)E.2 is partially rescued by cpb+t4.5

      (Whited et al., 2004)
      Comments

      Fails to complement lethality of cpbM143.

      (Whited et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated in an EMS screen for failure to complement cpbM143 lethality.

      (Whited et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cpbF44
      (Loya et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)