FlyBase Allele Report: Dmel\kkv[63-20]

General Information

Symbol

Dmel\kkv^63-20

Species

D. melanogaster

Name

FlyBase ID

FBal0179292

Feature type

allele

Associated gene

Dmel\kkv

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: E810K.

(Moussian et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:5,382,716..5,382,716 [-]

Nucleotide change:

G5382716A

Amino acid change:

E809K | kkv-PA; E809K | kkv-PC; E809K | kkv-PD

Reported amino acid change:

E810K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Moussian et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | recessive

(Moussian et al., 2005)

lethal | pupal stage | recessive | somatic clone

(Moussian et al., 2005)

Phenotype Manifest In

cephalopharyngeal skeleton

(Moussian et al., 2005)

embryonic/larval cuticle (with kkv^IB22)

(Moussian et al., 2015)

embryonic/larval tracheal section (with kkv^IB22)

(Moussian et al., 2015)

hypostomal sclerite

(Moussian et al., 2005)

median tooth

(Moussian et al., 2005)

vertical bridge

(Moussian et al., 2005)

Detailed Description

Statement

Reference

In kkv^IB22/kkv^63-20 mutants, the cuticular and luminal chitin of the tracheae is absent, and there are dilations and constrictions in the dorsal trunk and apical expansions in other branches. Defects in cuticle formation are also observed.

(Moussian et al., 2015)

The head skeleton of mature mutant embryos is only weakly melanised, especially in the labrum and H-piece. The morphology of the head skeleton is also abnormal, for example the vertical plate has lost its typical fibrous ultrastructure. Homozygous clones induced in the larval imaginal discs that form the adult body do not affect larval viability, but result in pupal lethality.

(Moussian et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

kkv^IB22/kkv^63-20 has embryonic/larval tracheal section phenotype, non-suppressible by Scer\GAL4^btl.PU/exp^UAS.RB

(Moussian et al., 2015)

kkv^IB22/kkv^63-20 has embryonic/larval tracheal section phenotype, non-suppressible by reb^UAS.cMa/Scer\GAL4^btl.PU

(Moussian et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

kkv^IB22/kkv^63-20 is rescued by Scer\GAL4^btl.PU/kkv^UAS.GFP

(Moussian et al., 2015)

Comments

Scer\GAL4^btl.PU-mediated expression of kkv^{Scer\UAS.T:Avic\GFP} rescues kkv^IB22/kkv^63-20 defects and restores luminal accumulation of chitin.

(Moussian et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CS-1/kkv^63-20

(Moussian et al., 2005)

kkv^63-20

(De Giorgio et al., 2023, Moussian et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close