FB2024_03 , released June 25, 2024
Allele: Dmel\sdΔ200.UAS
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General Information
Symbol
Dmel\sdΔ200.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0178078
Feature type
allele
Associated gene
Dmel\sd
Associated Insertion(s)
Carried in Construct
P{UAS-sd.Δ200}
Key Links
Transgenic product class
inframe_deletion
(Chow et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Chow et al., 2004)
Mutagen
in vitro construct
(Chow et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-sd.Δ200}
Cytology
Description

A cDNA fragment corresponding to a truncated form of sd (missing the first 200 amino acid residues) is expressed under the control of UASt regulatory sequences. The deletion removes all of the sd TEA domain.

(Chow et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
sd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of sdΔ200.Scer\UAS under the control of Scer\GAL4ptc-559.1 results in a protruding eye phenotype. Eye bristles are duplicated or missing and can have altered morphology, and ommatidia may have bristles at four of their vertices. Fusion of ommatidia is also seen and an ectopic cluster of cells is seen between the lamina and ommatidia that coincides with the eye protrusion.

      Expression of sdΔ200.Scer\UAS under the control of Scer\GAL4ptc-559.1 occasionally results in leg duplications. Loss of wing tissue and wing bristles is also seen in these flies.

      Expression of sdΔ200.Scer\UAS under the control of Scer\GAL4ptc-559.1 results in an increase in cell death only along the anterior/posterior boundary of the wing pouch. There is also increased cell death in the leg imaginal disc, and the leg disc may be duplicated.

      (Garg et al., 2007)

      Expression of sdΔ200.Scer\UAS, driven by Scer\GAL4vg.boundary, leads to an enhancement of the wing phenotypes seen in sdETX4 and sd58d mutants. Overexpression of sdΔ200.Scer\UAS driven by Scer\GAL4vg.boundary leads to a defective wing phenotype in wild-type flies.

      (Chow et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The defective wing phenotype seen when sdΔ200.Scer\UAS is expressed under control of Scer\GAL4vg.boundary in sdETX4 and sd58d mutants is alleviated when vgScer\UAS.cKa is overexpressed.

      (Chow et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sdΔ200.Scer\UAS
      sdΔ200.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)