FlyBase Allele Report: Dmel\Pvr[RNAi.UAS]

General Information

Symbol

Dmel\Pvr^RNAi.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0176041

Feature type

allele

Associated gene

Dmel\Pvr

Associated Insertion(s)

Carried in Construct

P{UAS-Pvr.RNAi}

Key Links

Transgenic product class

RNAi_reagent

(Ishimaru et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ishimaru et al., 2004)

Mutagen

in vitro construct

(Ishimaru et al., 2004, Ishimaru et al., 2004)

Progenitor genotype

Carried in construct

P{UAS-Pvr.RNAi}

Cytology

Description

UAS sequences drive expression Pvr coding sequences (from GenBank:AJ250859 nucleotides 314 to 1041) repeated in dyad symmetry.

(Ishimaru et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Pvr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

mesothoracic tergum, with Scer\GAL4^pnr-MD237

(Ishimaru et al., 2004)

microchaeta, with Scer\GAL4^pnr-MD237

(Ishimaru et al., 2004)

thorax, with Pvr^c02195, Scer\GAL4^pnr-MD237

(Ishimaru et al., 2004)

thorax, with Scer\GAL4^pnr-MD237

(Ishimaru et al., 2004)

Detailed Description

Statement

Reference

When Pvr^{dsRNA.Scer\UAS} is driven by Scer\GAL4^pnr-MD237, about 66% of mutants are nearly normal. However, the remaining 34% exhibit defects on their nota with the midline lacking bristles, or split thoraxes (5%). The penetrance of the split thorax phenotype increases with P{UAS-Pvr.IR} copy number. About 24% of Pvr^c02195/+, Pvr^{dsRNA.Scer\UAS}, Scer\GAL4^pnr-MD237 animals exhibit a split thorax phenotype.

(Ishimaru et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Pvr^RNAi.UAS, Scer\GAL4^Act5C.PI is a non-suppressor of neoplasia | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴

(Igaki et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, enhanceable by Cdc42⁴

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, enhanceable by Cdc42⁴

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, enhanceable by mbc^D11.2

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, enhanceable by mbc^D11.2

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, enhanceable by slpr⁹²¹

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, enhanceable by slpr⁹²¹

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, enhanceable by Crk[+]/Crk^KG00336

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, enhanceable by Crk[+]/Crk^KG00336

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, enhanceable by Rac2^Δ/Mtl^Δ/Rac1^J10

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, enhanceable by Rac2^Δ/Mtl^Δ/Rac1^J10

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, enhanceable by bsk²

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, enhanceable by bsk²

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, enhanceable by hep^r75

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, enhanceable by hep^r75

(Ishimaru et al., 2004)

NOT Enhanced by

Statement

Reference

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, non-enhanceable by Dsor1^LH110

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, non-enhanceable by Dsor1^LH110

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, non-enhanceable by Raf¹²

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, non-enhanceable by Raf¹²

(Ishimaru et al., 2004)

Suppressed by

Statement

Reference

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, suppressible | partially by puc^E69

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, suppressible by puc^E69

(Ishimaru et al., 2004)

NOT suppressed by

Statement

Reference

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, non-suppressible by Dsor1^LH110

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has mesothoracic tergum phenotype, non-suppressible by Raf¹²

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, non-suppressible by Dsor1^LH110

(Ishimaru et al., 2004)

Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237 has thorax phenotype, non-suppressible by Raf¹²

(Ishimaru et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Pvr^{dsRNA.Scer\UAS} (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system does not suppress metastatic behaviour in l(2)gl⁴ mutants expressing Ras85D^V12.Scer\UAS.

(Igaki et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pvr^RNAi.UAS

Pvr^{dsRNA.Scer\UAS}

Pvr^dsRNA.UAS

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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