pdm3^f00828 third instar larvae have a significantly elongated ventral nerve cord compared to wild-type controls.

In pdm3^f00828 third instar larvae a significant proportion of axons from vtd1 neurons of abdominal segments 4-6 contact the midline and collapse in the subesophageal ganglion (SEG). Dendrite morphology and initial axonal projections along the lateral tract, followed by a dorsomedial turn in the metathoracic segment and an anterior extension parallel to the midline towards the SEG are similar to wild-type controls.

Adult flies homozygous for pdm3^f00828 suffer a high rate of mortality due to locomotion defects resulting in the flies becoming stuck in the fly food.

Homozygous pdm3^f00828 mutant flies show reduced motility and a darkened cuticle, and have a shortened life span, with an average adult survival time of 4 days.

The number of neurons in the maxillary palp appears to be similar to wild type in pdm3^f00828 mutants (determined using elav staining).

pdm3^f00828 mutant flies fail to respond to odorants that elicit a train of action potentials in the pb1A olfactory receptor neuron (ORN) in wild-type, despite the fact that pb1A is present and yields spontaneous action potentials. In contrast, the neighbouring bp1B ORN responds normally to its most effective odorants (4-methyl phenol and 4-propyl phenol). Neurons of the pb2 and pb3 sensilla also give very similar responses in pdm3^f00828 and control animals. One of the four ORNs in the large basiconic sensilla, ab1A, is also unable to respond to odors, although it is present. No abnormalities are detected in the ORNs of the ab2 and ab3 sensilla.

pdm3^f00828/Df(2R)Exel6058 mutant flies fail to respond to odorants that elicit a train of action potentials in the pb1A olfactory receptor neuron (ORN) in wild-type, despite the fact that pb1A is present and yields spontaneous action potentials. In contrast, the neighbouring bp1B ORN responds normally to its most effective odorants (4-methyl phenol and 4-propyl phenol). Neurons of the pb2 and pb3 sensilla also give very similar responses in pdm3^f00828/Df(2R)Exel6058 and control animals.

The axonal projections of the pb1B and pb3A olfactory receptor neuron classes are abnormal. Rather than converging on a single, discrete glomerulus in each antennal lobe, the convergence in pdm3^f00828 mutants is less precise. Some axons appear to bifurcate, with axons occupying more than one region. The axons generally terminate in the vicinity of the wild type target, but not in the precise position of the wild type glomerular target.

pdm3^f00828 has abnormal neurophysiology | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Or42a^UAS.Tag:MYC

pdm3^f00828 has abnormal smell perception | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Or42a^UAS.Tag:MYC

acj6⁶, pdm3[+]/pdm3^f00828 has abnormal neurophysiology | adult stage phenotype

acj6⁶, pdm3[+]/pdm3^f00828 has abnormal smell perception | recessive | adult stage phenotype