FlyBase Allele Report: Dmel\Tsc1[f01910]

General Information

Symbol

Dmel\Tsc1^f01910

Species

D. melanogaster

Name

FlyBase ID

FBal0159590

Feature type

allele

Associated gene

Dmel\Tsc1

Associated Insertion(s)

PBac{WH}Tsc1^f01910

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{WH}Tsc1^f01910

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{WH}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:24,133,752..24,133,752 [+]

(Natarajan et al., 2013, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | somatic clone

(Hsieh et al., 2010)

Phenotype Manifest In

eye disc | somatic clone

(Hsieh et al., 2010)

eye disc morphogenetic furrow | somatic clone

(Hsieh et al., 2010)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Tsc1^f01910 has increased cell death | somatic clone phenotype, enhanceable by Rbf^120a

(Hsieh et al., 2010)

Tsc1^f01910 has increased cell death | somatic clone phenotype, enhanceable by Rbf^120a/E2f1^rM729

(Hsieh et al., 2010)

Suppressed by

Statement

Reference

Rbf^120a, Tsc1^f01910 has increased cell death | somatic clone phenotype, suppressible by E2f1^rM729

(Hsieh et al., 2010)

Enhancer of

Statement

Reference

Tsc1^f01910 is an enhancer of increased cell death | somatic clone phenotype of Rbf^120a

(Hsieh et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Tsc1^f01910 has eye disc | somatic clone phenotype, enhanceable by E2f1^rM729

(Hsieh et al., 2010)

Tsc1^f01910 has eye disc morphogenetic furrow | somatic clone phenotype, enhanceable by Rbf^120a

(Hsieh et al., 2010)

Tsc1^f01910 has eye disc | somatic clone phenotype, enhanceable by Rbf^120a

(Hsieh et al., 2010)

Tsc1^f01910 has eye disc | somatic clone phenotype, enhanceable by Rbf^120a/E2f1^rM729

(Hsieh et al., 2010)

Suppressed by

Statement

Reference

Rbf^120a, Tsc1^f01910 has eye disc | somatic clone phenotype, suppressible by E2f1^rM729

(Hsieh et al., 2010)

Rbf^120a, Tsc1^f01910 has eye disc morphogenetic furrow | somatic clone phenotype, suppressible by E2f1^rM729

(Hsieh et al., 2010)

Enhancer of

Statement

Reference

Tsc1^f01910 is an enhancer of eye disc anterior to the morphogenetic furrow | somatic clone phenotype of Rbf^120a

(Hsieh et al., 2010)

Tsc1^f01910 is an enhancer of eye disc morphogenetic furrow | somatic clone phenotype of Rbf^120a

(Hsieh et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Generating Tsc1^f01910 clones in Rbf^120a eye discs produce an increase in the level of ectopic cell death.

Tsc1^f01910 E2f^rM729 double mutant eye disc clones in a wild-type background are smaller than Tsc1^f01910 single mutant eye disc clones.

When Tsc1^f01910 E2f^rM729 double mutant clones are generated in Rbf^120a, the sizes of the Tsc1^f01910 E2f^rM729 double mutant clones are much smaller than that of Tsc1^f01910 single mutant clones.

The prevailing cell death phenotype observed in Rbf^120a Tsc1^f01910 double mutant clones at the morphogenetic furrow is no longer present in Rbf^120a E2f^rM729 Tsc1^f01910 triple mutant cells, indicating that the increased level of ectopic cell death observed in Rbf^120a Tsc1^f01910 double mutant cells is E2f-dependent.

(Hsieh et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

18488

w¹¹¹⁸; PBac{WH}Tsc1^f01910/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tsc1^f01910

tsc1^f01910

(Hsieh et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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