FB2024_03 , released June 25, 2024
Allele: Dmel\BursZ1091
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General Information
Symbol
Dmel\BursZ1091
Species
D. melanogaster
Name
FlyBase ID
FBal0159435
Feature type
allele
Associated gene
Dmel\Burs
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Dewey et al., 2004)
Progenitor genotype
Cytology
Description

Amino acid replacement: C115Y.

(Dewey et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,770,016..21,770,016 [+]
Nucleotide change:

G21770016A

Amino acid change:

C115Y | Burs-PA

Reported amino acid change:

C115Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Dewey et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The midguts of 10-14 day old BursZ1091/BursZ1091 mutants display intestinal stem cell proliferation, and abnormal epithelial multilayering, as compared with wild type.

      The midguts of 10-14 day old BursZ1091/+ mutants display intestinal stem cell hyperproliferation, as compared with wild type.

      (Scopelliti et al., 2014)

      As in wild type, no bursCCAP neurons are seen in the ventral nerve cord of BursZ1091 mutant flies at 3-4 days post-eclosion.

      (Lee et al., 2013)

      Homozygous, hemizygous and bursZ1091/bursZ5569 flies fail to spread their wings following eclosion and show prolonged retention of the elongate abdomen shape which is characteristic of a newly eclosed fly. By the day after eclosion, the abdomen has shortened, but it fails to taper into the normal adult shape, consistent with a failure to sclerotise properly. bursZ1091 adults pigment normally but fail to complete thorax expansion after eclosion, resulting in postscutellar bristles remaining crossed. bursZ1091/bursZ5569 adults are slow to pigment, with only 18% completing pigmentation within 3 hours of eclosion. These flies also have crossed postscutellar bristles.

      (Dewey et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      rk4/+ ; bursZ1091/+ double heterozygous flies show no defects in wing expansion or tanning.

      (Dewey et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      1091
      (McNabb and Truman, 2006)
      BursZ1091
      burs1091
      (Scopelliti et al., 2014)
      bursZ1091
      (Melnattur et al., 2020, Lee et al., 2013, Davis et al., 2007)
      bursz1091
      (Scopelliti et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)