FB2024_03 , released June 25, 2024
Allele: Dmel\DysEP3397
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General Information
Symbol
Dmel\DysEP3397
Species
D. melanogaster
Name
FlyBase ID
FBal0156626
Feature type
allele
Associated gene
Dmel\Dys
Associated Insertion(s)
P{EP}DysEP3397
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Christoforou et al., 2008)
Mutagen
P-element activity
(FlyBase, 1996-)
Progenitor genotype
Associated Insertion(s)
P{EP}DysEP3397
Cytology
Description

P{EP}DysEP3397 is located 750bp upstream of the Dys 'dystrophin-like protein 2' isoform initiator ATG.

(van der Plas et al., 2006)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  muscular dystrophy
      CEA
      (Catalani et al., 2021)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies whose posterior wing compartment is largely composed of clones of DysEP3397 homozygous mutant cells (induced in Minute/+ background to give them a growth advantage) show posterior cross vein (PCV) defects ('detached' PCV phenotype).

      (Schleede and Blair, 2015)

      1 week old DysEP3397/Df(3R)Exel6184 flies show increased systolic diameter, increased diastolic diameter and decreased fractional shortening compared to wild-type controls.

      (Taghli-Lamallem et al., 2014)

      det1/detEP3397 transheterozygotes show a posterior crossvein phenotype with 100% penetrance.

      detEP3397/Df(3R)Exel6184 transheterozygotes show a posterior crossvein phenotype with 100% penetrance. 4% of mutant wings have a "gapped" phenotype, 76% have a "detached" phenotype, 19% have a "point" phenotype and 1% are crossveinless.

      The number of hemocytes in the posterior crossvein region in detEP3397/Df(3R)Exel6184 pupal wings is either greatly reduced compared to wild type or they are completely absent.

      (Christoforou et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      detEP3397/Df(3R)ED5942 flies do not show the crossvein defect characteristic of det mutants, but show wing vein thickening.

      (Christoforou et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the insertion in detEP3397 reverts the mutant phenotype.

      (Christoforou et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      DysEP3397
      (Catalani et al., 2021, Christoforou et al., 2008)
      DysEP(3)3397
      (Taghli-Lamallem et al., 2014)
      det3397
      (Christoforou et al., 2008)
      detEP3397
      dysEP3397
      (Schleede and Blair, 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)