FB2024_03 , released June 25, 2024
Allele: Dmel\GclmL0580
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General Information
Symbol
Dmel\GclmL0580
Species
D. melanogaster
Name
FlyBase ID
FBal0156439
Feature type
allele
Associated gene
Dmel\Gclm
Associated Insertion(s)
P{lacW}GclmL0580
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Fraser et al., 2003)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{lacW}GclmL0580
    Cytology
    Description

    P{lacW} insertion in the 5' noncoding region of Gclm.

    (Fraser et al., 2003)
    Allele components
    Component
    Use(s)
    Inserted element
    P{lacW}
    Encoded product / tool
    lacZ
    Tagged with
    Tag:NLS(P)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  Parkinson's disease
        modeled by Hsap\SNCAUAS.cTa
        (Trinh et al., 2008)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        GclmL0580 animals are substantially more sensitive to arsenite than the Gclmrev controls.

        (Ortiz et al., 2009)

        GclmL0580 homozygotes do not exhibit loss of DA neuron integrity.

        (Trinh et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        GclmL0580 is an enhancer of abnormal neuroanatomy phenotype of Hsap\SNCAUAS.cTa, Scer\GAL4ple.PF

        (Trinh et al., 2008)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        GclmL0580 is an enhancer of dopaminergic neuron phenotype of Hsap\SNCAUAS.cTa, Scer\GAL4ple.PF

        (Trinh et al., 2008)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        The decreased Gclm activity in GclmL0580 homozygotes is found to significantly enhance the DA neuron loss induced by expression of Hsap\SNCAScer\UAS.cTa under the control of Scer\GAL4ple.PF.

        (Trinh et al., 2008)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer

        Separable from: l(3)L0580L0580. The lethality of the "l(3)L0580" chromosome (caused by l(3)L0580L0580) is separable from the P{lacW}GclmL0580 insertion, as judged by failure to recover dysgenically induced revertants, failure to rescue the lethality using a Gclm transgene and by deficiency mapping.

        (Fraser et al., 2003)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        GclmL0580
        (Trinh et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)