FlyBase Allele Report: Dmel\Psn[541.UAS]

General Information

Symbol

Dmel\Psn^541.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0156025

Feature type

allele

Associated gene

Dmel\Psn

Associated Insertion(s)

Carried in Construct

P{UAS-Psn.541.Exel}

Also Known As

UAS-Psn

Key Links

Transgenic product class

wild_type

(Parks, 2004.5.12)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Parks, 2004.5.12)

Mutagen

in vitro construct

(Parks, 2004.5.12)

Progenitor genotype

Carried in construct

P{UAS-Psn.541.Exel}

Cytology

Description

UAS regulatory sequences drive expression of the 541 amino acid isoform of Psn.

(Parks, 2004.5.12)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Psn

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Alzheimer's disease

CEA

(Reynolds-Peterson et al., 2020)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Alzheimer's disease

is ameliorated by sfl^HMS00543

(Reynolds-Peterson et al., 2020)

is ameliorated by ttv^GD1993

(Reynolds-Peterson et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^elav-C155

(Reynolds-Peterson et al., 2020)

Phenotype Manifest In

eye, with Scer\GAL4^elav-C155

(Reynolds-Peterson et al., 2020)

Detailed Description

Statement

Reference

Expression of Psn^541.UAS under the control of Scer\GAL4^elav-C155 leads to a reduction in the size of the eye as well as a disruption of patterning relative to controls.

(Reynolds-Peterson et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Psn^541.UAS, Scer\GAL4^elav-C155 has abnormal size | adult stage phenotype, suppressible by sfl^HMS00543, Scer\GAL4^elav-C155

(Reynolds-Peterson et al., 2020)

Psn^541.UAS, Scer\GAL4^elav-C155 has abnormal size | adult stage phenotype, suppressible | partially by ttv^GD1993, Scer\GAL4^elav-C155

(Reynolds-Peterson et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Psn^541.UAS, Scer\GAL4^elav-C155 has eye phenotype, suppressible | partially by sfl^HMS00543, Scer\GAL4^elav-C155

(Reynolds-Peterson et al., 2020)

Psn^541.UAS, Scer\GAL4^elav-C155 has eye phenotype, suppressible | partially by ttv^GD1993, Scer\GAL4^elav-C155

(Reynolds-Peterson et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

The decreased eye size phenotype of expression of Psn^541.UAS is suppressed by expression of sfl^HMS00543 and partially suppressed by expression of ttv^GD1993; while the disruption of eye patterning phenotype of expression of Psn^541.UAS is partially suppressed by expression of sfl^HMS00543 and non-suppressed by expression of ttv^GD1993 under the control of Scer\GAL4^elav-C155.