FB2024_03 , released June 25, 2024
Allele: Dmel\amos3
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General Information
Symbol
Dmel\amos3
Species
D. melanogaster
Name
FlyBase ID
FBal0155655
Feature type
allele
Associated gene
Dmel\amos
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(zur Lage et al., 2003)
Mutagen
ethyl methanesulfonate
(zur Lage et al., 2003)
Progenitor genotype
Cytology
Description

Contains a 230bp deletion that also causes a frameshift.

(zur Lage et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:18,596,587..18,596,815 [-]
Comment:

Inferred boundaries of a 229 base deletion that results in a frameshift after amino acid 30 and early translation termination after the addition of 44 novel amino acids. The deletion was reported as 330 bases in length but a deletion of 229 bases puts a stop codon in frame at the described location. Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

(zur Lage et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants have far fewer clusters of olfactory receptor neurons in the late pupal antenna. Mutant antennae have many fewer neuronal groups, corresponding in number to the sensilla coelonica and the ectopic bristles. There are instances of sensilla innervated by a single neuron, which appear to the ectopic bristles. The olfactory receptor neurons are thinner and consisting of fewer axons than wild-type, but are otherwise normal looking. In the pupal antennal imaginal disc of mutant animals, the first and second waves of sensory organ precursor formation appear to occur normally, but the third phase fails to occur.

      (zur Lage et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      amos3, rntod has basiconic sensillum phenotype

      (Li et al., 2013)

      amos3, rntod has trichoid sensillum phenotype

      (Li et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      rntod/rntot, amos3/Y double mutant males lack all basiconic and trichoid sensilla.

      (Li et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      amos3
      (Scalzotto et al., 2022, Sarov et al., 2016, Li et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)