Overexpression of smo^{Scer\UAS.cHa.T:Hsap\MYC} behind the morphogenetic furrow, under the control of Scer\GAL4^lz-gal4 generates rough eyes, with defects most pronounced in the posterior. At approximately 24 hours, pupal retinas are relatively normal, although primary cells are often misaligned (27%). By approximately 30 hours, pupal ommatidia exhibit reduced numbers of cone cells (16%) and of lattice cells (75%), with occasional cone cells adopting a rounded morphology characteristic of apoptotic cells. Photoreceptor differentiation, assessed by counting rhabdomeres in pupal retinas, is unaffected in these mutants.

Expression of two copies of smo^{Scer\UAS.cHa.T:Hsap\MYC} under the control of hemizygous Scer\GAL4^Bx-MS1096 results in the expansion of wing veins L1 and L3 and produces mild hypertrophy of the anterior wing. Expression of high levels of smo^{Scer\UAS.cHa.T:Hsap\MYC} under the control of Scer\GAL4^Bx-MS1096 is generally pharate lethal, while adult escapers show transformation of the entire anterior compartment of the wing into vein except for a small strip at the border. The ectopic venation and L3/4 narrowing caused by expression of smo^{C.Scer\UAS.T:Hsap\MYC,T:Uuuu\Myr4} under the control of Scer\GAL4^Bx-MS1096 is suppressed by co-expression of smo^{Scer\UAS.cHa.T:Hsap\MYC}.