Nucleotide substitution: T?A. Amino acid replacement: V134D.
T12736453A
T?A
V134D | Ptp69D-PA; V134D | Ptp69D-PB
V134D
At 25oC, the survival rates of homozygotes are: adult survival - 77%, eclosion - 80%, pupation 03%. At 18oC, the survival rates of homozygotes are: adult survival - 85%, eclosion - 93%, pupation 88%. Temperature shift experiments indicate that to survive after eclosion, Ptp69D1/Ptp69D10 animals must be shifted to the permissive temperature (18oC) from the restrictive temperature (25oC) as early pupae. The rate of eclosion drops from 100% at 18oC to 75% when Ptp69D1/Ptp69D10 animals are reared at 25oC for their first 24 hours and drops further to 40% if the animals are raised at 25oC until the early pupal stage. Ptp69D10 embryos show motor axon defects; 33% of ISNb axons, 14% of ISN axons, 22% of SNa axons and 4% of SNc axons show defects. 9% of ISNb axons show a complete bypass phenotype and 15% show a partial bypass phenotype.
Ptp69D10 has abnormal neuroanatomy phenotype, suppressible by Ptp99A[+]/Ptp99A1
Ptp69D10 has larval intersegmental nerve phenotype, suppressible by Ptp99A[+]/Ptp99A1