Nucleotide substitution: G?A. Amino acid replacement: C1097Y.
G12739527A
G?A
C1097Y | Ptp69D-PA; C1096Y | Ptp69D-PB
C1097Y
Mutation is in the active site at the catalytic cysteine residue.
At 25oC, the survival rates of homozygotes are: adult survival - 1%, eclosion - 3, pupation 11%. At 18oC, the survival rates of homozygotes are: adult survival - 1%, eclosion - 7%, pupation 35%. Ptp69D21 embryos show motor axon defects; 32% of ISNb axons, 5% of ISN axons, 5% of SNa axons and 3% of SNc axons show defects. 1% of ISNb axons show a complete bypass phenotype and 16% show a partial bypass phenotype.