FB2024_03 , released June 25, 2024
Allele: Dmel\msl-2ey.hs
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General Information
Symbol
Dmel\msl-2ey.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0151721
Feature type
allele
Associated gene
Dmel\msl-2
Associated Insertion(s)
Carried in Construct
P{y+YEM2}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Kelley and Kuroda, 2003)
Progenitor genotype
Carried in construct
P{y+YEM2}
Cytology
Description

Construct: A 3.6kb eye specific enhancer from an intron of ey is fused upstream of a minimal Hsp70 promoter driving expression of the msl-2 coding sequence (which lacks the regulatory Sxl protein binding sites in the msl-2 5' and 3' UTRs). The tra2 3' UTR and polyadenylation site is placed downstream of msl-2.

(Kelley and Kuroda, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
ey
Encoded product / tool
msl-2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of msl-2ey.hs results in a very mild rough eye phenotype in 2-5% of females.

      (Kelley and Kuroda, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      msl-2ey.hs has visible | female limited phenotype, enhanceable by msl-1Hsp83.PC

      (Kelley and Kuroda, 2003)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      msl-2ey.hs has eye phenotype, enhanceable by msl-1Hsp83.PC

      (Kelley and Kuroda, 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The rough eye phenotype seen in females expressing msl-2ey.hs is strongly enhanced by co-expression of msl-1Hsp83.PC, but males expressing both msl-2ey.hs and msl-1Hsp83.PC have wild-type eyes. The mini-w gene in P{GMroX1}102C is derepressed in females if they also express msl-2ey.hs.

      (Kelley and Kuroda, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      msl-2ey.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)