FB2024_03 , released June 25, 2024
Allele: Dmel\eyaS-A.UAS
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General Information
Symbol
Dmel\eyaS-A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0150508
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

Construct: Amino acid replacement: S?A.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The average penetrance of ectopic eye induction in eyaS-A.Scer\UAS; Scer\GAL4dpp.blk1 flies is 19% (over 8 independent P{UAS-eyaS-A} insertions). Ectopic eye patches seen in these flies are smaller than those seen in eyaScer\UAS.cHa; Scer\GAL4dpp.blk1 flies. i.e. - the penetrance of ectopic eye phenotypes is lower than that seen in eyaScer\UAS.cHa; Scer\GAL4dpp.PH flies. The penetrance of ectopic eye induction in eyaS-A.Scer\UAS; Scer\GAL4dpp.blk1 flies is reduced from 42% (n=306) to 20% (n=304) by heterozygosity for eyaG130 (data from a single, 'strong' P{UAS-eyaS-A} insertion). eyaS-A.Scer\UAS; Scer\GAL4dpp.PH flies have highly variable wing defects, including ectopic bristles on L3 and in more extreme cases, blistering, and defects in overall shape: Proportion with blistered wings = 14%; proportion with only mild wing defects = 71%, while 15% have wild-type wings. These flies also have increased numbers of scutellar machrochaete (average= 5.6, compared to 4 in wild-type). Expressivity of all of these phenotypes is lower than for eyaScer\UAS.cHa; Scer\GAL4dpp.PH flies. Note: all of the above data are averages from 8 independent P{UAS-eyaS-A} insertions.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

Scer\GAL4dpp.blk1, eyaS-A.UAS has eye | ectopic phenotype, suppressible | partially by rl[+]/rlS-135

Additional Comments
Genetic Interactions
Statement
Reference

The penetrance of ectopic eye induction in eyaS-A.Scer\UAS; Scer\GAL4dpp.blk1 flies is reduced from 42% (n=306) to 13% (n=310) by heterozygosity for rlS-135 (data from a single, 'strong' P{UAS-eyaS-A} insertion).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

These mutations of putative MAPK phosphorylation sites eliminate in vitro phosphorylation by rl, Mpk2 and p38b.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
eyaS-A.Scer\UAS
eyaS-A.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)