FB2024_03 , released June 25, 2024
Allele: Dmel\Sox15KG09145
Open Close
General Information
Symbol
Dmel\Sox15KG09145
Species
D. melanogaster
Name
FlyBase ID
FBal0147414
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
KG09145
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Insertion within the first intron.

Mutations Mapped to the Genome
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Most homozygous Sox15KG09145 flies die as pharate adults. The homozygous Sox15KG09145 escapers are weak and display held-out wings. The held-out-wing phenotype is the result of abnormalities in proximal hinge structures, such as the sclerites, the alula and the costa.

Sox15KG09145 mutant third instar larval wing imaginal discs show hinge overgrowth that causes extra folds both dorsally and ventrally. There is an increase in cell proliferation in the hinge region of Sox15KG09145 mutant L3 wing imaginal discs relative to the wild-type. The rate of apoptotic cell death is also increased in Sox15KG09145 mutant wing discs in the hinge region.

The wing pouch and body wall regions appear unaffected in Sox15KG09145 mutant third instar larval wing imaginal discs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

In wgspd-fg, Sox15KG09145 double mutant third instar larval wing imaginal discs, the distal hinge region is reduced in size compared to either single mutant. The rate of hinge-specific apoptosis is similar in wgspd-fg, Sox15KG09145 double mutant and Sox15KG09145 single mutant L3 wing discs.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)