Insertion within the first intron.
Most homozygous Sox15KG09145 flies die as pharate adults. The homozygous Sox15KG09145 escapers are weak and display held-out wings. The held-out-wing phenotype is the result of abnormalities in proximal hinge structures, such as the sclerites, the alula and the costa.
Sox15KG09145 mutant third instar larval wing imaginal discs show hinge overgrowth that causes extra folds both dorsally and ventrally. There is an increase in cell proliferation in the hinge region of Sox15KG09145 mutant L3 wing imaginal discs relative to the wild-type. The rate of apoptotic cell death is also increased in Sox15KG09145 mutant wing discs in the hinge region.
The wing pouch and body wall regions appear unaffected in Sox15KG09145 mutant third instar larval wing imaginal discs.
Sox15KG09145 is an enhancer of abnormal size | third instar larval stage | recessive phenotype of wgspd-fg
Sox15KG09145, wgspd-fg has abnormal size | recessive | third instar larval stage phenotype
Sox15KG09145 is an enhancer of wing hinge primordium phenotype of wgspd-fg
Sox15KG09145, wgspd-fg has wing hinge primordium phenotype
In wgspd-fg, Sox15KG09145 double mutant third instar larval wing imaginal discs, the distal hinge region is reduced in size compared to either single mutant. The rate of hinge-specific apoptosis is similar in wgspd-fg, Sox15KG09145 double mutant and Sox15KG09145 single mutant L3 wing discs.