FB2024_03 , released June 25, 2024
Allele: Dmel\shiK39A.GMR
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General Information
Symbol
Dmel\shiK39A.GMR
Species
D. melanogaster
Name
FlyBase ID
FBal0146811
Feature type
allele
Associated gene
Dmel\shi
Associated Insertion(s)
Carried in Construct
P{GMR-shiK39A}
Also Known As
GMR-shiK39A
Key Links
Transgenic product class
missense_variant
(Chang et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Chang et al., 2002)
Mutagen
in vitro construct
(Chang et al., 2002)
Progenitor genotype
Carried in construct
P{GMR-shiK39A}
Cytology
Description

GMR regulatory sequences drive expression of a mutated shi coding sequence; carries the K39A mutation, rendering the shi protein GTP-hydrolysis defective.

(Chang et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
shi
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      shiK39A.GMR expression causes a rough eye phenotype, which becomes more severe with further copies of the shiK39A.GMR transgene.

      (Chang et al., 2004)

      Expression partially inhibits the internalization of boss in eye discs. Causes a rough eye phenotype.

      (Chang et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      shiK39A.GMR has visible phenotype, enhanceable by Hsc70-4HS1-25/Hsc70-4[+]

      (Chang et al., 2002)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      shiK39A.GMR has eye phenotype, enhanceable by Hsc70-4HS1-25/Hsc70-4[+]

      (Chang et al., 2002)

      shiK39A.GMR has ommatidium phenotype, enhanceable by Hsc70-4HS1-25/Hsc70-4[+]

      (Chang et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      shiK39A.GMR
      Name Synonyms
      Secondary FlyBase IDs
        References (3)