FlyBase Allele Report: Dmel\trio[123.4]

General Information

Symbol

Dmel\trio^123.4

Species

D. melanogaster

Name

FlyBase ID

FBal0146746

Feature type

allele

Associated gene

Dmel\trio

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Giniger, 2003.7.28)

Progenitor genotype

trio^S036810

(Giniger, 2003.7.28)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with trio¹)

(Song and Giniger, 2011)

Phenotype Manifest In

larval intersegmental nerve branch ISNb of A1-7 (with trio¹)

(Song and Giniger, 2011)

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage

(Kannan et al., 2017)

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage (with trio⁸)

(Kannan et al., 2017)

Detailed Description

Statement

Reference

trio⁸/trio^123.4 embryos display stalling of the ISNb motor nerve at the junction of muscles 6 and 13 with failure to innervate muscle 12 in >65% of hemisegments examined. trio^123.4 heterozygous show the stalling phenotype (observed in 16% of examined hemisegments).

(Kannan et al., 2017)

trio¹/trio^123.4 mutants display a specific axonal defect in ISNb, 'stalling' in the middle of the target field.

(Song and Giniger, 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

N^l1N-ts1, trio^123.4/trio[+] has abnormal neuroanatomy | heat sensitive phenotype, enhanceable by Scer\GAL4^elav-C155/trio^UAS.cBa

(Song and Giniger, 2011)

Suppressed by

Statement

Reference

N^l1N-ts1, trio^123.4/trio[+] has abnormal neuroanatomy | heat sensitive phenotype, suppressible by Scer\GAL4^elav-C155/trio^GEF1mu.UAS

(Song and Giniger, 2011)

NOT suppressed by

Statement

Reference

N^l1N-ts1, trio^123.4/trio[+] has abnormal neuroanatomy | heat sensitive phenotype, non-suppressible by Scer\GAL4^elav-C155/trio^GEF1mu.UAS

(Song and Giniger, 2011)

Suppressor of

Statement

Reference

trio^123.4/trio[+] is a suppressor of abnormal neuroanatomy | heat sensitive phenotype of N^l1N-ts1

(Song and Giniger, 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

trio^123.4 has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, enhanceable by SCAR^Δ37/SCAR[+]

(Kannan et al., 2017)

N^l1N-ts1, trio^123.4/trio[+] has larval intersegmental nerve | heat sensitive phenotype, enhanceable by Scer\GAL4^elav-C155/trio^UAS.cBa

(Song and Giniger, 2011)

N^l1N-ts1, trio^123.4/trio[+] has larval intersegmental nerve branch ISNb of A1-7 | heat sensitive phenotype, enhanceable by Scer\GAL4^elav-C155/trio^UAS.cBa

(Song and Giniger, 2011)

Suppressed by

Statement

Reference

N^l1N-ts1, trio^123.4/trio[+] has larval intersegmental nerve | heat sensitive phenotype, suppressible by Scer\GAL4^elav-C155/trio^GEF2mu.UAS

(Song and Giniger, 2011)

N^l1N-ts1, trio^123.4/trio[+] has larval intersegmental nerve branch ISNb of A1-7 | heat sensitive phenotype, suppressible by Scer\GAL4^elav-C155/trio^GEF2mu.UAS

(Song and Giniger, 2011)

N^l1N-ts1, trio^123.4/trio[+] has larval segmental nerve branch SNa of A1-7 | heat sensitive phenotype, suppressible by Scer\GAL4^elav-C155/trio^GEF2mu.UAS

(Song and Giniger, 2011)

NOT suppressed by

Statement

Reference

trio⁸/trio^123.4 has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Abl^UAS.cFa

(Kannan et al., 2017)

N^l1N-ts1, trio^123.4/trio[+] has larval intersegmental nerve | heat sensitive phenotype, non-suppressible by Scer\GAL4^elav-C155/trio^GEF1mu.UAS

(Song and Giniger, 2011)

N^l1N-ts1, trio^123.4/trio[+] has larval intersegmental nerve branch ISNb of A1-7 | heat sensitive phenotype, non-suppressible by Scer\GAL4^elav-C155/trio^GEF1mu.UAS

(Song and Giniger, 2011)

N^l1N-ts1, trio^123.4/trio[+] has larval segmental nerve branch SNa of A1-7 | heat sensitive phenotype, non-suppressible by Scer\GAL4^elav-C155/trio^GEF1mu.UAS

(Song and Giniger, 2011)

Enhancer of

Statement

Reference

trio^123.4/trio[+] is an enhancer of larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype of SCAR^Δ37

(Kannan et al., 2017)

Suppressor of

Statement

Reference

trio^123.4/trio[+] is a suppressor of larval intersegmental nerve | heat sensitive phenotype of N^l1N-ts1

(Song and Giniger, 2011, Crowner et al., 2003)

trio^123.4/trio[+] is a suppressor of larval intersegmental nerve branch ISNb of A1-7 | heat sensitive phenotype of N^l1N-ts1

(Song and Giniger, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

SCAR^Δ37/+;trio^123.4/+ double heterozygous embryos show stalling of the ISNb motor nerve at the junction of muscles 6 and 13 with failure to innervate muscle 12 in 51% of examined hemisegments - a strongly increased penetrance compared to either of the single heterozygotes.

The stalling of the ISNb motor nerve at the junction of muscles 6 and 13 with failure to innervate muscle 12 characteristic for trio⁸/trio^123.4 mutant embryos is not suppressed by Scer\GAL4^elav.PU-driven expression of Abl^Scer\UAS.cFa in the mutant background.

(Kannan et al., 2017)

A trio^123.4 heterozygous background significantly restores the ability of ISNb axons to enter the ventrolateral muscle field in N^l1N-ts1 mutants. This suppression is reverted upon pan-neural expression of trio^Scer\UAS.cBa under the control of Scer\GAL4^elav-C155.

Pan-neuronal expression of trio^{GEF1mu.Scer\UAS} in a N^l1N-ts1; trio^123.4/+ background (under the control of Scer\GAL4^elav-C155) does not restore the ability of ISNb axons to enter the ventrolateral muscle field.

Pan-neuronal expression of trio^{GEF2mu.Scer\UAS} in a N^l1N-ts1; trio^123.4/+ background (under the control of Scer\GAL4^elav-C155) restores the ability of ISNb axons to enter the ventrolateral muscle field.

(Song and Giniger, 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

trio^123.4

(Kannan et al., 2017, Song and Giniger, 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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