FlyBase Allele Report: Dmel\w[69C]

General Information

Symbol

Dmel\w^69C

Species

D. melanogaster

Name

FlyBase ID

FBal0146688

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

P{GMroX1}ara^69C

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kelley and Kuroda, 2003, Park et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{GMroX1}ara^69C

Cytology

Description

P{GMroX1} insertion in the second intron of ara.

(Kelley and Kuroda, 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color | female

(Kelley and Kuroda, 2003, Park et al., 2002)

abnormal eye color | male

(Kelley and Kuroda, 2003, Park et al., 2002)

Phenotype Manifest In

eye | female | ventral

(Kelley and Kuroda, 2003)

eye | male | ventral

(Kelley and Kuroda, 2003)

pigment cell | female

(Kelley and Kuroda, 2003, Park et al., 2002)

pigment cell | male

(Kelley and Kuroda, 2003, Park et al., 2002)

Detailed Description

Statement

Reference

Eye colour: the dorsal 30% of the eye is pigmented in hemizygotes of both sexes, but the ventral 70% is completely white in females and sectored in males carrying one copy of w^69C in a w^- background. Males homozygous for w^69C in a w^- background have eyes with nearly solid red pigmentation with a lighter equator. About 10% of females homozygous for w^69C in a w^- background have a small pigmented sector in the ventral half of the eye.

(Kelley and Kuroda, 2003)

Eye colour: females carrying w^69C in a w^- background only show expression of w in the dorsal part of the eye (w expression is silenced in the ventral 70% of the eye). Eye colour: males carrying w^69C in a w^- background show expression of w in the dorsal part of the eye and in addition have sporadic red sectors in the ventral part of the eye.

(Park et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

w^69C has abnormal eye color | female phenotype, non-enhanceable by Df(1)52/lncRNA:roX1^ex6

(Park et al., 2002)

Suppressed by

Statement

Reference

w^69C has abnormal eye color | male phenotype, suppressible by Pc³

(Kelley and Kuroda, 2003)

w^69C has abnormal eye color | female phenotype, suppressible by Pc³

(Kelley and Kuroda, 2003)

w^69C has abnormal eye color | male phenotype, suppressible by Df(1)52/lncRNA:roX1^ex6

(Park et al., 2002)

NOT suppressed by

Statement

Reference

w^69C has abnormal eye color | female phenotype, non-suppressible by Df(1)52/lncRNA:roX1^ex6

(Park et al., 2002)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

w^69C has pigment cell | female phenotype, non-enhanceable by Df(1)52/lncRNA:roX1^ex6

(Park et al., 2002)

Suppressed by

Statement

Reference

w^69C has eye | ventral | female phenotype, suppressible by Pc³

(Kelley and Kuroda, 2003)

w^69C has eye | ventral | male phenotype, suppressible by Pc³

(Kelley and Kuroda, 2003)

w^69C has pigment cell | female phenotype, suppressible by Pc³

(Kelley and Kuroda, 2003)

w^69C has pigment cell | male phenotype, suppressible by Pc³

(Kelley and Kuroda, 2003)

w^69C has pigment cell | male phenotype, suppressible by Df(1)52/lncRNA:roX1^ex6

(Park et al., 2002)

NOT suppressed by

Statement

Reference

w^69C has pigment cell | female phenotype, non-suppressible by Df(1)52/lncRNA:roX1^ex6

(Park et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Pc³ results in a weak derepression of w expression in the ventral part of the eye in both males and females carrying one copy of w^69C in a w^- background.

(Kelley and Kuroda, 2003)

Eye colour: the expression of w^69C in females carrying w^69C in a w^- background is unchanged if they are also carrying roX1^ex6 Df(1)52 P{w⁺4Δ4.3}. Eye colour: males carrying w^69C in a w^- background that are also carrying roX1^ex6 Df(1)52 P{w⁺4Δ4.3} show almost complete derepression of w^69C expression in the ventral part of the eye.

(Park et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

w^69C

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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