FB2024_03 , released June 25, 2024
Allele: Dmel\PRAS40P17
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General Information
Symbol
Dmel\PRAS40P17
Species
D. melanogaster
Name
FlyBase ID
FBal0144765
Feature type
allele
Associated gene
Dmel\PRAS40
Associated Insertion(s)
P{PZ}PRAS40P17
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Son and Choi, 2020)
Mutagen
Delta2-3 transposase
(Chern and Choi, 2002)
Progenitor genotype
P{PZ}PRAS4002637
(Chern and Choi, 2002)
Associated Insertion(s)
P{PZ}PRAS40P17
Cytology
Description

Local transposition of the P{PZ} element in CG4614602637, resulting in a P{PZ} element in the first exon of CG46146, 163bp downstream of the start codon.

(Chern and Choi, 2002)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes are viable and develop normally without any visible phenotype in the eye.

      (Son and Choi, 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      PRAS40[+]/PRAS40P17 is a non-enhancer of visible | dominant phenotype of L2

      (Son and Choi, 2020)
      NOT Suppressor of
      Statement
      Reference

      PRAS40[+]/PRAS40P17 is a non-suppressor of visible | dominant phenotype of L2

      (Son and Choi, 2020)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      PRAS40[+]/PRAS40P17 is a non-enhancer of eye phenotype of L2

      (Son and Choi, 2020)
      NOT Suppressor of
      Statement
      Reference

      PRAS40[+]/PRAS40P17 is a non-suppressor of eye phenotype of L2

      (Son and Choi, 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      PRAS40P17/+ partially suppresses the small eye phenotype caused by expression of PRAS40UAS.cCa under the control of Scer\GAL4ey.PU.

      (Son and Choi, 2020)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      The P{PZ}PRAS40P17 chromosome was originally isolated as a lethal mutation that interacted genetically with an allele of L, enhancing the Lsi/+ eye phenotype (FBrf0151277). However, the lethality is a second site mutation and is separable from the P{PZ}PRAS40P17 insertion. A P{PZ}PRAS40P17 chromosome in which the second site lethal has been removed is homozygous viable, does not show any visible eye phenotype and does not modify the eye phenotype of L2.

      (Son and Choi, 2020)
      Comments
      Comments

      Precise excision of the P{PZ} element reverts the mutant phenotype.

      (Chern and Choi, 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG46146P17
      LP17
      PRAS40P17
      (Son and Choi, 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)