FB2024_03 , released June 25, 2024
Allele: Dmel\CamB1234Q.UAS
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General Information
Symbol
Dmel\CamB1234Q.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0141863
Feature type
allele
Associated gene
Dmel\Cam
Associated Insertion(s)
Carried in Construct
P{UAS-Cam.B1234Q}
Key Links
Transgenic product class
missense_variant
(Wang et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Wang et al., 2002)
Mutagen
in vitro construct
(Wang et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-Cam.B1234Q}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of Cam in which the all four Ca[2+] binding sites have been inactivated by E to Q changes.

(Wang et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Cam
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of CamB1234Q.Scer\UAS under the control of Scer\GAL4how-24B in Cam7/+ animals (which are normally phenotypically wild type) results in minor wrinkling of the pupal case but overall survival to adulthood is unaffected.

      (Wang et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      CamB1234Q.UAS/Scer\GAL4elav.PLu fails to rescue Camn339

      (Wang et al., 2003)

      CamB1234Q.UAS/Scer\GAL4how-24B fails to rescue Cam7/Camn339

      (Wang et al., 2002)
      Comments

      The spontaneous backward movement seen in homozygous Camn339 larvae is not rescued by expression of CamB1234Q.Scer\UAS under the control of Scer\GAL4elav.PLu.

      (Wang et al., 2003)

      Expression of CamB1234Q.Scer\UAS under the control of Scer\GAL4how-24B has little effect on the pupal case phenotype of Cam7/Camn339 mutants, although a smaller percentage of larvae survive to the pupal stage. 2.3% of the animals that pupate eclose.

      (Wang et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CamB1234Q.Scer\UAS
      CamB1234Q.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)